Will any exogenous DNA in a human germ cell be passed to offspring?

[stester77s]

Will any exogenous introduced DNA in a human germ cell, whether it is incorporated into a chromosome or not, be passed to offspring?

Solutions for practice tests say yes, but I didn't think this was a guarantee that it would be passed on. Please explain as well.

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[DrknoSDN]

I don't see how that could be the answer. For it to be passed on it would need to avoid being digested by cytosolic enzymes, have sequences that allow for replication, have centromeres for proper distribution during replication etc.

Maybe they were talking about entire chromosomes.
But if you injected non genomic DNA that was entirely composed of restriction sequences that would allow cytosolic restriction enzymes to chop it into little pieces, i don't think it would be passed on.
Lots of scenarios would prevent exogenous DNA from being replicated so I don't see how it could be passed to offspring.

Can you share the books explanation?

 

[stester77s]

I don't see how that could be the answer. For it to be passed on it would need to avoid being digested by cytosolic enzymes, have sequences that allow for replication, have centromeres for proper distribution during replication etc.

Maybe they were talking about entire chromosomes.
But if you injected non genomic DNA that was entirely composed of restriction sequences that would allow cytosolic restriction enzymes to chop it into little pieces, i don't think it would be passed on.
Lots of scenarios would prevent exogenous DNA from being replicated so I don't see how it could be passed to offspring.

Can you share the books explanation?

Thank you for the reply and all your replies to my threads so far. I really appreciate them all.

This came from a solutions sheet. It concerned one of the wrong answer choices:
Wrong answer choice:
D) No, because foreign DNA is not passed to offspring

Solutions sheet:
"Furthermore, any DNA contained within a germ line cell, be it original cellular DNA or introduced DNA, will be passed on. [so D is incorrect]"

D I think was actually wrong because it was not the best answer choice (it may or may not be passed on to offspring - you can't say it with certainty and generality) and the solutions sheet had a facile/wrong answer, since they only dedicated one short sentence to it.