Xofigo

[ohioapplicant]

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Any role for RadOncs to administer drugs like Xofigo?

 

[Gfunk6]

In short, yes. Plenty of Rad Oncs do it.

 

[medgator]

Did my first case yesterday.

Yes many do although it's sometimes done by nuc med depending on geography and politics

 

[Cancerdancer]

We are doing them all in our practice, hasn't even been a conversation about whether us or Nuc Med. There are good consults to see, as I've seen a few with large mets in the proximal femurs that I've run by Ortho and/or done a short course of EBRT while waiting for Xofigo to process/arrive. Same with spine mets, I often throw in 20/5 if bulky/threatening cord. Med Oncs and certainly Nuc Meds don't think about these local issues as we do.

 

[Grubbe]

We are doing them all in our practice, hasn't even been a conversation about whether us or Nuc Med. There are good consults to see, as I've seen a few with large mets in the proximal femurs that I've run by Ortho and/or done a short course of EBRT while waiting for Xofigo to process/arrive. Same with spine mets, I often throw in 20/5 if bulky/threatening cord. Med Oncs and certainly Nuc Meds don't think about these local issues as we do.

That's a very good point and I completely agree.

 

[seper]

how do you guys figure out use of this drug around chemo regimens?

 

[medgator]

how do you guys figure out use of this drug around chemo regimens?

It's pretty straight forward (I think). It's only approved for metastatic castrate-resistant prostate CA with symptomatic bone mets, without evidence of visceral mets (since Xofigo only has a predilection for targeting bone).

If someone presents to me with visceral metastatic disease, I'd send them for chemo (and if their PS isn't great, I believe there is some data now for Zytiga, and soon for Xtandi)