Step I Zonisamide

[Pox in a box]

Zonisamide??????????????????????

Kaplan's USMLE Edge calls this a drug worth knowing. 😕 😴 👎 😎

 

[bigfrank]

I got it on Step I. 😉

 

[doc05]

it's an antiseizure drug. btw, I've never seen it on the wards.

 

[HiddenTruth]

It's a sulfa drug, whose MOA is really unknown. But, it supposedly acts by blocking Na and Ca channels (in vitro studies). It also facilitates dopaminergic and 5HT transmission, and a weak CA inhibitor (like topiramate).

Dose adjust for RF, long t 1/2--like phenobarb
SE: nephrolithiasis (like topiramate), SJ rash, agranulocytosis, psychiatric symptoms (psychosis, depression), in pedes: hyperthermia.

I think that should cover all the big stuff.

 

[Pox in a box]

I got it on Step I. 😉

And...?

 

[bigfrank]

And...?

I got it right. Was a question regarding usage for epilepsy -- no other choice was antiseizure. no biggie

 

[Harrie]

Zonisamide??????????????????????

Kaplan's USMLE Edge calls this a drug worth knowing. 😕 😴 👎 😎

Every drug is worth knowing for Step I!