AML treatment?

[elburrito]

Would an AML (FAB classification AML M0 - AML with minimal differentiation; WHO AML, NOS) be treated differently from something a pathologist calls, "Acute undifferentiated leukemia"?

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[gutonc]

Would an AML (FAB classification AML M0 - AML with minimal differentiation; WHO AML, NOS) be treated differently from something a pathologist calls, "Acute undifferentiated leukemia"?

Nope. Hematopathologists love to get worked up about this stuff but the reality is that, as long as it's not APL, they're getting the same chemo (unless going on a study).

I have a friend who is a leukemia specialist and is married to a hematopathologist. It's hilarious to watch them argue about this.

 

[visari]

yeah these fancy AML WHO classifications are pretty useless when it comes to treatment... but when you say "acute undifferentiated leukemia" do you mean myeloid undifferentiated or true biphenotypic? because people usually treat the later with ALL-like regimens (i.e hyper-CVAD or BFM or whatever with IT stuff) since these have cytarabine and an anthracycline anyway.

 

[Doctor&Geek]

Ditto to visari. We give our undiff's MEC here followed by transplant.