Compounding question

[pharmacy7424]

If a recipe calls for adding enough liquid vehicle to 'wet' the powder, to make a 'fine paste,' how much liquid needs to be added?

If one adds excessive liquid than is necessary to 'wet' the powder, can that damage the final product? It seems like if it is all going into the suspension anyway, what is the harm in adding extra liquid to the powder initially.

If a tablet or capsule is not on 'do not crush' lists, is it generally safe to triturate it, for adding to a suspension?

---

Members don't see this ad.

 

[KidPharmD]

First Question: Enough... You add a little bit, then a little more, until it looks right.
Second Question: Depends on if you are using a different wetting agent and suspending agent. As long as you don't use more than the allowable amount of wetting agent for the recipe, you are generally okay.

Third question: NO. You have to know WHY this is not on the list. Most of these "do not crush" products are extended release. Often times trying to crush the Extend release mechanism (matrix for example) will ruin your product. Now, are some products safe for this use, probably. I still wouldn't go as far as to say, "generally" safe.