Diluting Omnipaque?

[GlowInTheDark]

Any of you been diluting Omnipaque for in-office use? We can only get 350mg/mL bottles and are tossing the idea around of diluting

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[stsa84]

I've been diluting. All I can get is 300mg/mL and 350mg/mL. Dilute down to close to 240. For the 350mg/mL, that's 2cc contrast to 1cc saline, final concentration of 233 mg/mL.

 

[Agast]

I don’t see why not.

I did a kyphoplasty and diluted the contrast going into the balloon. It does make it harder to visualize but not horrible so.

 

[GlowInTheDark]

I've been diluting. All I can get is 300mg/mL and 350mg/mL. Dilute down to close to 240. For the 350mg/mL, that's 2cc contrast to 1cc saline, final concentration of 233 mg/mL.

That’s what we were tossing around, 2:1. You think a 1:1 with 175 mg/mL would have good visualization?

 

[BobBarker]

We have been diluting for kyphoplasties without issue.

 

[Taus]

I asked the same question to the Pharmacist consultant at my asc. See attached. Bottom line- don’t use 350 or 140 on esi, diluted or not. Similar level of concern as Gadolinium on my end.

 

[BobBarker]

We are diluting isovue M to not waste the whole bottle.

 

[GlowInTheDark]

I asked the same question to the Pharmacist consultant at my asc. See attached. Bottom line- don’t use 350 or 140 on esi, diluted or not. Similar level of concern as Gadolinium on my end.

I believe you can get pyrogen free 350 and 140. I’m trying to understand reason for IT contraindication but can’t find much clarification from labeling and FDA.

 

[Ducttape]

ive been "diluting" down omnipaque for years.

draw up 2-3 cc, use oh say 0.5 cc in to the LOR syringe, add maybe 2 to 3 ml NS to taste, and inject away.

if i cant see the omnipaque in the LOR syringe on CLO, then attach the remaining 1-2 ml omnipaque.

 

[runfastnow]

We dilute down to Omnipaque 300 to somewhere around 180-200. Only time it causes a problem is on very obese patients - try to remember not to dilute those cases. Haven't seen any clinical outcome difference. Can still see vascular flow when it occurs.