Does withdrawal of beta blocker cause rebound hypertension?

[whaleshark]

I don't get why it makes rebound hypertension.
because of upregulated beta receptors, this phenomenon seems to be occur.
but beta 2 R stimulation will cause lowering blood pressure I guess. (dilation of vessels in skeletal muscle)
so, it may results in hypotension or tachycardia by beta 1 stimulation.. not hypertension
Arterial Pressure = CO * TPR
CO = HR * SV
I don't think increase of HR can overcome decrease of TPR enough.
give me some advice

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[zelman]

Do you believe that giving someone an epinephrine IV will raise their blood pressure? It's the same effect. The dilation of skeletal muscle arteries by beta receptor stimulation has evolved to allow them to get the additional blood-flow needed to run away from a threat or kill it. It's not significant enough to overcome the increase in heart rate and contractility.

 

[whaleshark]

Thank you! I understood it
Isoproterenol lowering mean blood pressure by beta 1 antagonism got me confused
So I thought effect of dilatation of vessels in skeletal muscles could be substantial
But not as I expected in fact.

I'm studying pharmacology in med school this semester
I'm not sure if this pharmacy forum is right place where I can ask these things
Or should I post in step or kind of other forums..?
Anyway thank thank you

 

[PharMed2016]

Post on the Step I forum.