Genetics gene symbol question

[TryingOnceMore]

Doing an online search, I was not able to find this.

What does the symbol -/- after a gene mean? For example, abcx2-/-

I'm thinking this probably signifies that both alleles are negative for a trait, but just wanted to confirm.

Thanks for any help!

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[bearintraining]

It's a knock-out or null allele.. it means the gene is nonfunctional/absent

 

[EverStriving]

Doing an online search, I was not able to find this.

What does the symbol -/- after a gene mean? For example, abcx2-/-

I'm thinking this probably signifies that both alleles are negative for a trait, but just wanted to confirm.

Thanks for any help!

Careful with conflating traits and genes.

abcx2+/+ means that the individual has two functioning copies of the gene (usually wild-type).
abcx2+/- means that the individual has only one functioning copy (heterozygous null/knock-out).
abcx2-/- means that the individual has no functioning copies (homozygous null, full knock-out).

 

[TryingOnceMore]

Thank you, Bear and Ever - just what I was looking for!