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GPAT and NIPER prepration guidance ..

Discussion in 'Pharmacy' started by NCPA, Aug 20, 2011.

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  1. NCPA

    NCPA National Community Pharmacists Association Partner Organization

    Aug 28, 2008
    SDN Partner NCPA SDN 2+ Year Member

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    From the NCPA Student Affairs Site

    Syllabus overview for GPAT/NIPER.
    Ø Lachman – chapter 1 to 7 are important. Chapter 8, 11 – 22 are to be done from this book. Tables on page number are important – 27, 37,44,98, 151,165,174,321,357
    (only ingredients),416 (onlyingredients),419,434,453,463,467,508,514,515518,521,522,
    551570 (names only), 621,631, 634, 642, 646 (tricky question like most permeable can be asked), 648.
    Ø Martin – if you read Subramanyam whole, then do chapter 1, and last 2 chapters (biomaterials and delivery systems from it.)
    Ø Brahmankar – whole book, read units of various parameters. CDDS. Remember various release models.
    Ø Cosmetics - remember only general things from B. M. Mitthal.
    Ø R. M mehta – Posology, calculations are important.
    Ø Cooper-gun – read method for sterilization of various injections given at the end of
    book.Containers, surgical instruments and sterilization at least see if u get time.
    Ø Extra – stability testing, ICH guidelines, drug approval process like NDA, ANDA, ORANGE BOOK.
    Ø Intellectual property rights (NIPER only).
    Ø What is being studied in niper is also asked.(that leave to us)

    Ø Gmp guidelines.


    Ø Rang and dale remains the standard book for GPAT/NIPER. (do all important tables from it.)
    Ø K.D TRIPATHI – see heamatology, cancer, antibiotics, disinfectants and vaccines from it.
    Ø See adverse drug reactions from ROGER-WALKER book.
    Ø Clical trials.
    Ø Pharmacological classification from KDT only.

    Medicinal chemistry:
    Ø Wilson – read only following things:
    Ø Structures of important drugs(s) and their starting material.(sm)

    For Structures :

    Dapsone, Isoniazid, Ethambutol, Pyrizinamide, Metronidazol, Methoxy Penicillin, Chloroquine, Ampicilin, Chlorpromazine, Haloperidol, Diazepam. Glutethimide, Phenobarbitone, Nikethamide, Isoprenaline, Ephedrine, Propranalol, Neostigmine, Furosemide, Hydrochlorthiazide, Lignocaine, Procaine, Diphenhydramine, Pethidine, Indomethacin, Phenylbutazone, Thyroxine, Acetozolamide, Thiotepa, Cloxacillin, Nephazoline, Phentolamine, Streptomycin, Penicillin, Nitrofurantoin, Thiobendazole, Digitoxin, Atropine, Cocaine, Methotrexate, Trimethoprim, Clonidine, Phentoin, Papverine, Quinine, Chlorthalidone, Hydralazine, Mepyramine, Promathazine, Cyclizine, Cetrizine, Cyproheptadine, Triprolidine, Astemizole, Cimetidine, Ranitine, Antazoline, Tripelennamine, Benzocaine, Ketamine, Thiopentone, Valproic Acid, Carbamazepine, Methohexital, Amitryptiline, Testosterone, Progesterone, Hydrocortisone, Diethylstilbesterol, Dienesterol, Ethacrynic Acid, Allopurinol, Captopril, Proparanalol, Guanethidine, Dextropropoxyphene. Ibuprofen , Fentanyl, Indomathacin, Prednsolone, Betamethasone, Triamicinolone, Cortisone, Estradiol, Cholesterol, Stanozolol, Probenecid, Ketoconazole, Amphotericin, Nystatin, Primaquin, Artemisin, Gentamicin,Neomycin, Erythromycin, Ampicilin, Amoxicillin, Tranyl Cypromine, Chloramphenicol,
    Metronidazole, Mebendazole, Thiabendazole, Cyclophophamide, Chlorambucil, Cisplatin, Diloxanide Furoate, Trimethoprim, Mefloquine, Mafenide, Amantidine, Zidovudine, Stavudine, Lamivudine, Foscarnet, Ganciclovir, Acyclovir, Alprazolam, Triazolam, Diazepam, Buspirone, Promazine, Pargyline, Guanadrel, Terazosin, Dopamine, Dobutamine, Noradrenaline, Atenolon, Pralidoxime, Isoprenaline, Pyridostigmine, Tacrine, Papaverine, Naloxone, Naltrexone, Morphine, Triamterene, Amiloride, Diltiazem, Verapamil, Nifedipine, Amlodipine, Atropine, D- Tubocurarine, Succinyl Choline, Emetine, Hydralazine, Reserpine, Vit. E, Tocopherols, Vit. A, Spiranolactone, Caffeine, Codeine, Piperacillin, Ticarcillin, Idoxiuridine, Fluorouracil, Metformin, Rosiglitazone, Glipizide, Gliburide, Busulfan, Mercaptopurine, Melphalan,Methyl Dopa, Minoxidil, Sulindac, Flucortisone, Ciprofloxacin, Gatifloxacin,Tamoxifen, Tolbutamide, Bupivacaine, Clomiphene, Diethyl Carbamazepine, Undecylenic Acid,Flucytosine, Griseofulvin, Terbinafine, Tolnaftate, Miconazole, Itraconazole, Lomefloxacin,Piperazine, Ivermectin, Kanamycin, Gentamicin, Minocycline, Rolicycline, Clindamycin, Vancomycin, Colistin, Polymixin, Bacitracin, Gramicidin, Mechlorethamine, Ifosfamide, Procarbazine, Carboplatin, Hydroxyurea, Ketamine, Propofol, Halothane,Primidone, Gabapentin, Theophylline, Theobromine, Amphetamine, Sibutramine, Buproprion, Phenylephrine, Tolazoline, Phentolamine, Donepezil, Edrophonium, Torasemide, Nitroglycerin, Digoxin, Enalapril, Losartan, Valsartan, Clofibrate, Gemfibrozil, Fenofibrate, Nicotinic Acid, Probucol, Warfarin, Glimepiride, Propyl Thiouracil, Methimazole, Clemastine, Loratidine, Famotidine, Progesterone, Structure Of All Vitamins, Atovastatin(Lipitor), Simvastatin.

    Starting Material:

    Dapsone, Isoniazid, Etahmbutol, Pyrizinamide, Chloroquine, Ampicilin,Chlorpromazine, Haloperidol, Diazepam. Glutethimide, Phenobarbitone, Nikethamide, Isoprenaline,Ephedrine, Propranalol, Neostigmeine, Furosemide, Hydrochlorthiazide, Lignocaine, Procaine, Diphenhydramin, Pethidine, Indomethacin, Phenylbutazone, Thyroxine, Acetozolamide,
    Thiotepa, Cloxacillin, Nephazoline, Digitoxin, Atropine, Cocaine, Methotrexate, Trimethoprim, Clonidine, Phentoin, Papverine, Quinine, Mepyramine, Promathazine,Cyclizine, Cetrizine, Cyproheptadine, Triprolidine, Astemizole, Cimetidine, Ranitine, Antazoline, Benzocaine, Ketamine, Valproic Acid, Carbamazepine, Methohexital, Amitryptiline, Testosterone, Progesterone, Hydrocortisone, Diethylstilbesterol, Dienesterol, Ethacrynic Acid, Allopurinol, Captopril, Proparanalol, Guanethidine, Dextripropoxyphene. Ibuprofen, Indomathacin, Prednisolone, Betamethasone,
    Triamicinolone, Cortisone, Estradiol, Cholesterol, Stanozolol, Chloramphenicol, , Diloxanide Furoate, Trimethoprim, Mefloquine, Amantidine, Diazepam, Dopamine, Dobutamine, Noradrenaline, Atenolol, Pralidoxime, Isoprenaline, Pyridostigmine, Diltiazem, Verapamil, Nifedipine, Amlodipine, Atropine, D-Tubocurarine, Succinyl Choline, Emetine, Hydralazine, Clofibrate, Gemfibrozil, Fenofibrate, Nicotinic Acid, Sulindac, Progesterone, Edrophonium, Nephazoline (These Are Enough) –

    important SAR related point:

    E:g position responsible for acid instability of erythromycin. No of isomers for particular drug.
    Active isomer. Group responsible for activity of drug.

    Which class drug belongs (chemical class, not pharmacological. Pharmacological class from K.D TRIPATHI only)

    Steroid chapter is very important.
    Iupac you can see of above drugs from Harkishan Singh book.just see the structure u will notice how iupac is given..for some of above drugs IUPAC mIght be complex and lengthy or not found just leave it.
    Ø Bioisosterism.
    Ø COMPFA like softwares.(NIPER) – LEAVE TO US
    Ø IUPAC from Harkishan Singh book only.


    Ø Kokate remains the standard book.
    Ø Whole book.
    ü B.s, c.c, synonym, use, adulterant, chemical test, substitute, structure (of imp drugs)
    ü If there are less adulterants or less info about adulterants in Kokate see Trease and Evans for further.
    Ø Earlier chapters general introduction are important from Kokate.
    Ø Trease-Kvans -see flavonoids and quality control chapter from it.
    Ø Who guidelines – Kokate is good but with limited information. See other book.
    Ø Caretenoids – Agrawal is good book. Remember only no of double bonds, structure, use.
    Ø Biochemical pathways – remember starting points.
    Ø Amino acids from which alkaloids are derived are to be remembered E:g tropane alkaloids from ornithine.
    Ø Microscopy of following drugs:
    Ø Read Khandelwall book other then above microscopies full.

    Organic chemistry :

    Ø Read only name reactions: Hoffman rearrangement etc (Mehta and Mehta or Morrison/Boyd)
    Ø Stereochemistry from (M/M or M/M).
    Ø Various catalyst from M/M E:g lindlar catalyst,wilkinson catalyst
    Ø General concepts from – M/M
    Ø Glossary of M/M

    Inorganic chemistry:

    Ø Bahl and Tuli only –thermodynamic and nuclear pharmacy chapters are very important. Other chapters are also important.
    Ø Chatwal – remember only common names of compounds and their use and water for injection limits.

    Microbiology :

    Ø Only Kokare (whole book) is enough. For microbiological tests see INAMDAR.
    Ø Vaccines read from it and also ip.
    Ø Something from Tortora (For Niper – we will say later).
    Ø Diagnostic tests.

    Biochemistry :

    Ø Satyanarayan is enough:
    Do chapters 1 to 7 and metabolism chapters. Do all important tables.
    Ø Biochemical teats (from R.K. GOYAL - available in GUJARAT only others students should see SATYANARAYAN AND KALE BOOK)
    Ø Fermentation causing microorganism from inamdar.

    Pharma analysis:

    Ø KARL-FISCHER/KJELDAHL/CAURIUS/DUMAS etc determination methods - bahl and bahl or any other book.
    Ø See analysis part from /REMINGTON also.
    Ø Circular dichromism.
    Ø Chromatography – RAVISHANKAR/KASTURE.


    Ø Gk jani/ kuchekar.
    Ø Read important years.
    Ø D and c act
    Ø Schedules
    Ø Form numbers
    Ø Members
    Ø Place of various institutes.

    Niper only
    Ø Biostatistics general concepts
    Ø Management/accountancy/partnership: use Gujarat board 11 or 12 standard books like – accountancy, secretial practice etc or what is studied in NIPER.
    Ø Noble prize winners recent.
    Ø Pharma news recent
    Ø General knowledge.
    Ø Apptitude (Maths)
    Ø Recent approved usfda druigs (do only approved in may/june/july –upto niper exam date)
    Ø Banks full forms and when they established.

    Ø Pharmaceutical full forms.
    Ø Name and location of important institutes.
    Ø Any other useful information which we say at last time.
    Ø The things which are being studied in niper are also asked. Most of this we will include in postal /series until you read above things.
    ALL THE BEST...:)

  2. blackvin30


    Dec 8, 2011
    Pharmacy Student
    this is one of the best gpat guidance post i have ever come across after a long tiring internet search.Thanks a lot.Could you provide some study material if possible...please

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