There are an increasing amount of schools (>20) that no longer have required coursework, but rather "preferred" or "suggested" or "recommended" coursework. So to your point, the expectation is that applicants have completed their undergraduate degrees at accredited universities and have proven competencies in science. It is unlikely my acceptance with be rescinded, at least not because of incompletion of non-required coursework.
For example:
Vanderbilt
Duke
Tulane
Mayo
Thank you, thank you. I'm sending good vibes your way, fingers crossed.
Like
@wysdoc mentioned, I made sure to take a very targeted approach building my school list which I believe is more important for non-traditional students (and seems to get looked over in general). I completed my application like I was applying to a job, or a very annoyingly agreeable date, I mirrored my application to be the applicant they wanted.
The unconventional approach starts here. My biggest concern was my undergraduate grades and proving I had scientific competencies, so I knew I had to have a decent MCAT score, my recommendation letters had to mention my penchant for science, and I had to lean into anything that could support my academic viability. I hired traditional students in their last semester before matriculating into medical school, spent less time/money than I would've if I had taken the courses, and paid them handsomely instead. My score isn't stellar, ~510, but I took it once. I'm not saying anyone should do this, I'm saying don't let, "If you don't, they will take acceptance back" discourage you from doing it the way they've misconceived is the only way. I appreciate all of the expert advice I've read online, but only you really know what your application needs.
Your unconventional approach is having these schools waive certain requirements, and putting it out there lets others know what's possible and other ways to approach the same goal.