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Is anyone familiar with the "Ketamine Coma" and it's role in pain mngmt?
Is anyone familiar with the "Ketamine Coma" and it's role in pain mngmt?
"The problem unfortunately is that we have so many horrible diseases related to the brain and so few drugs," said Bita Moghaddam, neuroscience professor at the University of Pittsburgh who uses ketamine in rats to mimic schizophrenic symptoms. "If you have a drug you think is relatively safe, you have to use what you have."
This is one thing that makes me so interested in pharmaceuticals targeted at the nervous system- there's a lot of experimentation. For example, dextromethorphan (active ingredient in Robitussin) used for levodopa-induced dyskinesia in Parkinson's and GHB approved for narcolepsy use. The drugs are just chemicals that produce a response in the nervous system, and the goodness or badness comes from how those effects relate to us.
Anyway I know our neurology dept uses ketamine for CRPS, although not to a multi-day coma effect. If the mechanism is really via the drug's role as NMDA antagonist, I wonder if Namenda would be useful at all. Does anyone know if Namenda is used off label for pain control or if any research has been done to that effect?
Anyway I know our neurology dept uses ketamine for CRPS, although not to a multi-day coma effect. If the mechanism is really via the drug's role as NMDA antagonist, I wonder if Namenda would be useful at all. Does anyone know if Namenda is used off label for pain control or if any research has been done to that effect?