Greetings all, I have tried to research how MME are actually determined with little success. Does anybody have any good referance articles on how MME was orginally started/determined? Was talking to a colleague who mentioned it was intially started by giving patients differnt meds and asking feedback on how strong these meds were. Sounds pretty out there and I have never been able to find anything online/my ref books other then a bunch of articles on how to calculate MME. I am more interested on how MME was intially deteremined and now changed (ie Tramadol). Thank you in advance.