Nuclear replication vs. DNA replication

[kirayuki29]

Hi guys,

In taking the nextstep diagnostic test, i came across a question in the biology section on nuclear and dna replication. i was wondering what nuclear replication encompasses- does it encompass both dna replication and cytoplasmic replication? basically is it like regular mitosis?

Thanks!

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[Lawpy]

Take a look at the following diagram:

Nuclear replication likely refers to mitosis since a nucleus disintegrates and two new nuclei are soon formed just before the cell divides. So nuclear replication refers to the mitotic/M phase of the cell cycle. DNA replication occurs in the S phase in interphase, and thus takes place before nuclear replication occurs. Once the DNA is replicated, the cell enters G2 phase to grow more and synthesize mitotic and other important proteins before entering M phase. Just before entering mitosis, the cell stops at the G2-M cell cycle checkpoint to check and repair for any DNA damage that occurs from DNA replication.