Why can't we use Avelox for UTI? Give me a good reason then prove it.
Quinolone in UTI
- Thread starter ZpackSux
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It doesn't swim well....too afraid to get into the pool...there is totally a diagram on the way...
Because its not indicated and it says so in that thick packet called the medication guide or whatever its called...you know that huge piece of fold out paper that has the tiny writing on it...Actually, I dont know why...I guess I should know why...
c'mon....put on your clinical hat and get cerebral.
active drug doesn't appear in the urine at concentrations sutible to treat an UTI
Is that right.. what % of Avelox is renally cleared?
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As for the above..I don't know off the top of my head...I'd say...10-15%? Those chicks are pretty damn hot, man....
ehh...good try mike. But not exactly.
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Sanford says 20%....I was closeish. I overestimated the hotness of my chicks. And why is that bad outisde of not killing said bug in bladder... you've got the rare possibility of quinolone resistance via that whole mechanism where it sets up that efflux protein thingy that spits out the antimicrobial molecule...I bet it's fun to watch if we ever set up a microscope that could see it happen...
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....but...but....I just looked it up and it said it's because insufficient unchanged drug reaches the bladder....
It wouldn't surprise me if there is some other explanation...but that's what they told me at a random hospital a few months ago, too...
EDIT: Oh, wait, you were talking about my arbitrary guess...yeah..it's a guess...
And what % is eliminated unchanged? How many step mutation does it require for resistance with Avelox vs other quinolones? How do you know it's not bactericidal in urine? Are you sure?
article said:
Reference: Urinary concentrations and bactericidal activities of newer fluoroquinolones in healthy volunteers
International Journal of Antimicrobial Agents, Volume 24, Issue 2, August 2004, Pages 168-172
Gary E. Stein and Sharon Schooley
Facts and Comparisons also states that 20% of unchanged drug appears in the urine
And you believe that random hospital... in WV I might add.
And your source says insufficient unchanged drug reaches the bladder...
So what exactly is the MIC for ecoli of the urine against Avelox vs Levaquin, vs Cipro?
I really dont know and my brain hurts really bad...Whats the answer??
EXCELLENT!!! Now..have you read the article by Stein? I can email it to you if you want.
keep reading.
npage. So against pseudomonas, UBA lacked in Moxifloxacin. But this is after 1 dose. What about other common bugs found in UTI..and what about after repeated dosing?
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The book said 20%...
I don't know...never really interested enough to find out.
As Doctor M said so eloquently...the guidelines say its useless, dammit...that's enough for me. Though I guess the concentrations needed to have bactericidal effects would likely have patient-specific (renal failure, hepatic failure) and bug-specific implications (already quinolone resistent...), too.
Clearly not.
That's all I know personally...I COULD go look it up, but somebody else will and post the answer to which you ask...probably pretending they actually knew the answer off the bat...which is fine with me....I just really don't like doing actual work at 11:45PM on a school night...
galant effort.
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Nah..lazy effort. If it were galant, I'd be on pubmed looking for {mesh}moxifloxacin AND {mesh}pharmacokinetics right now...
I glanced at the article. From my moderately competent understanding of ID. It looks like Moxi is ok against E.coli (The most common UTI pathogen) IT looks poorer against K. Pneumo and Psuedomonas. The guys is also paid by every other quinolone maker except Bayer
Edit: So, sure use it for a UTI if you want
Edit: So, sure use it for a UTI if you want
Actually, Moxi MIC is about 50% (2X more potent) of Levo for E Coli, K.Pneumo, and Enterocococcus. Schering paid. They make Avelox. Ortho paid, they make Levo.
npage,
Thanks for participating. I can confidently say that for most of you guys, this may be the first and only time you'll read that Avelox (moxifloxacin) can be used for UTI with susceptible organisms.
It also proves that today, we're more influenced by marketing based medicine rather than evidence based medicine.
I hope this has been enlightening for some of you.
Thanks for participating. I can confidently say that for most of you guys, this may be the first and only time you'll read that Avelox (moxifloxacin) can be used for UTI with susceptible organisms.
It also proves that today, we're more influenced by marketing based medicine rather than evidence based medicine.
I hope this has been enlightening for some of you.
"You can't take Levaquin off the formulary because what happens if a patient comes in with both penumonia and UTI? We need Levaquin" has been the most frequently used argument posed by physicians who are coached by Ortho McNeil sales reps.
And you answer it like npage just did.
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thanks, npage, you saved me from actually doing work, I commend you.
That is pretty cool though.
That is pretty cool though.
And Mike...you were on right track.
and M... dood.
and M... dood.
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and M... dood.
He's a graduate...he doesn't give a flying **** anymore...I'm sure I'll be the same way...
I personally hate therapeutics. I find it incredibly boring. I dig the pure receptor-intermediate-whathaveyou pharmacology and biochemistry, though. I just need to figure out a way to get a job involving those two areas without actually getting a PhD in pharmacology.
Im still pissed about that B**ch from the docs office...All I ever see is Bactrim, cipro and macrobid...Yes I named all name brands cause Im too lazy to type out the generics
Im still pissed about that B**ch from the docs office...All I ever see is Bactrim, cipro and macrobid...Yes I named all name brands cause Im too lazy to type out the generics
be honest..you know you can't spell Trimethoprim/Sulfamethoxazole and Nitrofurantoin.
What drugs are those??????
Stupid Doctors receptionist....😡
more importantly... is she hot?
Nah..thread is over. Answered correctly. My intention was to learn you guys something new today.
If it was a therapeutics question... I would give 93 out of 100.
no one will ever answer my question 100% unless you're reading my mind.
but npage was scary close...even cited the article I was using to base my argument. Kwinkadinka? Perhaps to a degree... but an educated conicidence.
but npage was scary close...even cited the article I was using to base my argument. Kwinkadinka? Perhaps to a degree... but an educated conicidence.
A conspiracy...btw, you should be an academic professor...No one would ever get an "A".
cute girls will always get an A...
Yeah, I would say so...Id have to agree.
I grade on a beauty curve..
LOL!
this thread will set a record for the most replied with the least viewed thread.
