I was a Microbiology, Immunology and Molecular Genetics major and a Psychology major. (the first one was nuts.) I did mention the 4 years briefly in my PS but I didn't emphasize it because they were going to see it on the transcript anyway. I focused more on how I got myself out of that situation. In the interview they definitely asked me about it, and I definitely was prepared and had an answer that not only addressed the weakness but how I ended up benefiting from my "youthful" choice at that point in time. It also helps because I knew I wasn't slacking off in school, but it was mostly a matter of circumstance, overloading, and time conflicts which caused the situation. In a way because I knew my GPA sucked the first four years, I knew that they were for sure going to ask me about it, so I had months of preparation to practice delivering that answer outloud. Believe you me, that's the one answer I wanted to make sure I delivered well naturally, not negatively, and with clarity and logic behind it.
Lol and in case you're worried that it was a one-hit wonder, I actually received interview offers to Oklahoma, Howard, and UMB. I turned down Oklahoma since UMB (my top choice) had already accepted me at that point. Howard waitlisted me. So don't give up hope!
