1. P

    Compilation of irreversible competitive inhibitors?

    The only irreversible competitive chemicals/drugs that comes to my mind are Aspirin, phenoxybenzamine, and (maybe CO toxin? or that one maybe just has a REALLY high affinity and may be CONSIDERED irreversible). Does anyone have a compilation of these irreversible competitive inhibitors? feel...
  2. LIC2015

    Enzyme Kinetics - what's the real reason for Vmax changes?

    Competitive inhibitors don't change Vmax, while uncompetitive/noncompetitive inhibitors do. Why? They all do the same basic thing - prevent substrate from being processed by the enzyme. But the way they do it is different. However, for the purposes of my question, please address the following...