1,25-hydroxylase synthesis

[Lonely Sol]

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Where in Kidney specifically does 1,25-OH happens? I couldnt find it in FA..it just says kidneys.

Thanks

 

[AndyRSC]

From one of Goljan audios:

Sites of synthesis: ACE - endothelium of pulmonary capillaries; erythropoietin - endothelial cells of peritubular capillaries; 1-alpha-hydroxylase - renal proximal tubule cells.

 

[Lonely Sol]

From one of Goljan audios:

Sites of synthesis: ACE - endothelium of pulmonary capillaries; erythropoietin - endothelial cells of peritubular capillaries; 1-alpha-hydroxylase - renal proximal tubule cells.

Thanks...I had a hunch it was PCT but I didnt know where I heard it from or where I read it. Really appreciate you clearing it up for me!