Step I 17 alpha hydroxylase def and aldosterone level

[MudPhud20XX]

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Can anyone explain why you would get low/normal aldosterone in 17 alpha hydroxylase def? I think it should give rather high aldosterone since the metabolic flux will be increased due to the blockage of conversion of pregneneolone to 17-hydroxypregnenolone.

 

[NagisaStar]

Since the precursors of aldosterone are weak mineralcorticoids (corticosterone etc.), their elevation causes a weak aldosterone like effect and therefore your body does not need to make as much aldosterone.

 

[el_duderino]

Suppression of the RAAT system because of those weak mineralacorticoids.

 

[673441]

Can anyone explain why you would get low/normal aldosterone in 17 alpha hydroxylase def? I think it should give rather high aldosterone since the metabolic flux will be increased due to the blockage of conversion of pregneneolone to 17-hydroxypregnenolone.

Agree with the poster above me. It's due to aldosterone's weak MC effect. And the fact that it increases volume expansion which ultimately suppresses RAAS, which pretty much acts as a negative inhibitor to further aldosterone secretion by the adrenals. Review the hypothalamic-pituitary-adrenal axis and that should further clarify things a bit.


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[Qester]

I just had an Rx question on this and in the explanation it stated that mineralcorticoids were increased, specifically aldosterone.

So I have no idea which way to think.

 

[el_duderino]

I just had an Rx question on this and in the explanation it stated that mineralcorticoids were increased, specifically aldosterone.

So I have no idea which way to think.

UpToDate clearly states that aldosterone and renin are suppressed in 17-hydroxylase deficiency.

 

[Qester]

UpToDate clearly states that aldosterone and renin are suppressed in 17-hydroxylase deficiency.

Thanks for the clarification 🙂
I hate when resources contradict each other.