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- Mar 10, 2012
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Hi, I just wanted to clarify: I know 2,3 BPG reduces oxygen affinity in hemoglobin causing it to release oxygen in active tissues. However, I read online that while 2,3 BPG increases with decreasing pH, 2,3 BPG mutase, which creates 2,3 BPG, is inactivated at low pH's. How is this possible? Thank you.