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Does 2,3 BPG bind to myoglobin?

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Stephen2009

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To the best of my knowledge only Hemoglobin binds 2,3 BPG.

Myoglobin doesn't exhibit cooperativity b/c it's only one "subunit", whereas hemoglobin has 4 subunits...

Myoglobin's O2 dissociation curve is hyperbolic whereas Hb's is sigmoidal... this means only Hb exhibits allosteric coopertivity. 2,3-bpg decreases the affinity of O2 by stabalizing the Tense state (vs. relaxed state.)

Hope this helped.
 
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boaz

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BPG works by binding in the space BETWEEN the subunits in hemoglobin. Myoglobin has just one monomer, so BPG cannot possibly affect it.
 
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