a few questions.. your answers appreciated

[chef]

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1. osteoporosis - why is pulsatile PTH indicated as Rx, if bone mass is already low?

2. nifedipine (non-dihydro) vs amlodipine (dihydro) - if nifedipine doesnt work on the heat muscle cells and has no effect on the heart, shouldnt it be called a dihydro after all...?


got a few others but this is it for now..🙂

 

[commander]

1. osteoporosis - why is pulsatile PTH indicated as Rx, if bone mass is already low?
2. nifedipine (non-dihydro) vs amlodipine (dihydro) - if nifedipine doesnt work on the heat muscle cells and has no effect on the heart, shouldnt it be called a dihydro after all...?
got a few others but this is it for now..🙂

1.pulsatile PTH is indicated for bone mass loss. it enhances bone formation.
2.I haven't reviewed pharm in a long time, but from what I remember, I there are three groups: virapamil (cardioselective), diltiazam ("inbetween") and -dipines. all drugs that end with -dipines have the same property. that is how I memorized. make sure you check it.

another advice, don't get stuck on minor details --> keep moving.

 

[Lamborghini1315]

1. osteoporosis - why is pulsatile PTH indicated as Rx, if bone mass is already low?

2. nifedipine (non-dihydro) vs amlodipine (dihydro) - if nifedipine doesnt work on the heat muscle cells and has no effect on the heart, shouldnt it be called a dihydro after all...?


got a few others but this is it for now..🙂

We are doing cardio right now..so i can probably help here. First, try to remember that non-dihydropines are better drugs for the heart since they don't affect the smooth muscle. While the dihydropines have an impact on calcium channels of both the heart and smooth muscle-vasculature. So it would make sense to stick to non-dihydro's if you are exclusively trying to effect the heart contractility. You have it wrong,amlodine and nifedipine are both dihydropines but some studies have shown that amlodipine exerts less negative inotropic effects and is longer acting than nifedipine. In other words nifedipine has shown to have far more adverse side effects..thus you should prefer amlodipine over nifedipine. I will forgo answering your first question because i don't have a clue at this point.