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But how in the world can you memorize irrelevant details from m1 all the way until boards? Isn't it just too much detail that it's almost impossible to memorize
Not really. There is some detail that's probably a little extreme, but I would say that much of it actually ends up being important. I remember hearing first years this fall talking about the crazy details they had to memorize, and then proceeded to list as examples a number of things that are actually quite relevant both to step 1 and clinically. I think it's hard to know what exactly is important in the early stages, and you only really know what was high/low yield AFTER you take your exam.
You can do some triage with memorizing by letting yourself forget things that can be easily re-learned right before boards. Some of the biochem probably falls into this category, especially all those rare inborn errors they love to test. Otherwise, I think learning it really well the first time will make it much easier to refresh your memory later. Beyond that, taking some time to review and refresh as you go along is probably a good thing. Question banks are a great way to do this while also refining your testing skills, and it ensures that you really only study things you need to review while letting you blaze past the easier stuff.