AML and splenomegaly?

Thread starter MudPhud20XX
Start date Sep 17, 2014

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MudPhud20XX

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Sep 17, 2014

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A 35-year-old man has a worsening productive cough for a month. On physical examination, he has small nontender lymph nodes palpable in axillae, and the tip of his spleen is palpable. Laboratory studies show Hgb 10 g/dL, Hct 31%, MCV 90 fL, WBC count 79,000/µL, and platelet count 30,000/µL. Microscopic examination of his peripheral blood smear shows many blasts with Auer rods. Which of the following is the most likely diagnosis?

AML is the answer of course. I am wondering if palpable spleen (splenomegaly) is associated with AML. Any idea?