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Ok, so here might be a basic/dumb question for y'all.
In first aid, in the antianginal therapy section, it says that B-blockers help angina by affecting afterload. Is this right, and if so what's the mechanism? I know that B-blockers can decrease BP via it's negative inotropic/chronotropic effects leading to decreased cardiac output, but what about afterload? As I understand it, afterload is a measure of aortic or peripheral resistance, so how are B-blockers affecting this? If anything, a nonspecific beta-blocker like propranolol would cause an INCREASE in TPR via blocking beta-2 mediated vasodilatation. Can someone please clarify this issue for me? Thanks!
In first aid, in the antianginal therapy section, it says that B-blockers help angina by affecting afterload. Is this right, and if so what's the mechanism? I know that B-blockers can decrease BP via it's negative inotropic/chronotropic effects leading to decreased cardiac output, but what about afterload? As I understand it, afterload is a measure of aortic or peripheral resistance, so how are B-blockers affecting this? If anything, a nonspecific beta-blocker like propranolol would cause an INCREASE in TPR via blocking beta-2 mediated vasodilatation. Can someone please clarify this issue for me? Thanks!