Annoying/Simple Thyroid Hormone Question

[nectarine]

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On UWORLD, I just got a question wrong. It was basically blah blah blah what does thyroid hormone have.

A. cytoplasmic receptor
B. nuclear receptor

UWORLD said nuclear receptor, but I remembered from BRS that they said that thyroid hormone diffuses across the membrane, binds its receptor, and then the receptor-hormone complex enters the nucleus, dimerizes, and binds SREs. So i said cytoplasmic receptor. Which is correct?

 

[psychforme]

b

 

[Guyton Killah]

On UWORLD, I just got a question wrong. It was basically blah blah blah what does thyroid hormone have.

A. cytoplasmic receptor
B. nuclear receptor

UWORLD said nuclear receptor, but I remembered from BRS that they said that thyroid hormone diffuses across the membrane, binds its receptor, and then the receptor-hormone complex enters the nucleus, dimerizes, and binds SREs. So i said cytoplasmic receptor. Which is correct?

TREs

 

[stickshift]

Nuclear.

Goljan says so.

 

[Neon Goat]

Just in case someone stumbles across this in a search like I did, from Wikipedia (hehe):

In the field of molecular biology, nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules.

I can see myself choosing cytoplasmic receptor b/c I remember that the receptor is in the cytosol, but I have to remember that the name of the receptor is "nuclear receptor." That's why it's the right answer.

 

[ChiDO]

Steroids and Thyroid = Nuclear
Insulin = Membrane

 

[username456789]

Steroids and Thyroid = Nuclear
Insulin = Membrane

I don't think anyone was confused with that distinction. The hang up was the nuance that many "nuclear receptors" often bind their ligands in the cytoplasm before translocating to the nucleus. Despite this, they are indeed called "Nuclear Receptors", so technically that's the correct answer.

 

[InTheMaking]

Nuclear