Antithrombin inhibits ________

[username456789]

FA says 2/9a/10a/11a/12a on one page, then just a few later it says 2/7/9/10/11 I think (I don't get wireless where I study and I forgot to take FA with me to post this).

What's the real story? Obviously I know warfarin plays around with 2/7/9/10.

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[MilkmanAl]

I believe the former is correct.

 

[norealname]

Antithrombin inactivates factors 2a (Thrombin), 9-12 (intrinsic pathway), and factor 7 (extrinsic pathway)

 

[username456789]

Cool. I guess this another instance of FA including partial info on a topic in one place, and different partial info on the same subject elsewhere, in the hopes that we'll hunt it down and piece it together on our own. Happens a lot with things like med side effects.

 

[badasshairday]

X and thrombin (II) are the only really important ones.

 

[username456789]

Oh also, anyone know why XIII isn't evaluated by a PTT? I'll be honest, I didn't even know there was a XIII until Step studying. We never learned that.

 

[norealname]

aPTT initiates coagulation in the intrinsic pathway by activating Factor XII (Coalin, the main reagent in aPTT activates Factor XII), skipping the steps done by Factor XIII.