antithrombin III

[docmd2010]

Which factors does this inhibit?

Goljan in his book says that it is factors XII, XI, IX, X; prothrombin and thrombin but in his audio he says that it is XII, XI, IX, VII, X; prothrombin and thrombin...

which one is correct?

thanks!

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[Nicholaus]

Which factors does this inhibit?

Goljan in his book says that it is factors XII, XI, IX, X; prothrombin and thrombin but in his audio he says that it is XII, XI, IX, VII, X; prothrombin and thrombin...

which one is correct?

thanks!

It is my understanding that AT-III inhibits the intrinsic pathway of the coagulation cascade (i.e. Factors XII, XI, IX, X, II, and I).

Perhaps someone else can confirm this!

Regards.

 

[bgreet]

removed

 

[Helo]

Apparently it not only takes out activated factors 12, 11, 9, 10, 2 but it can also inactivate activated factor 7...so it affects the extrinsic (i.e. tissue factor pathway), intrinsic, and common pathways. can anyone else confirm this?

sorry for using the numbers instead of roman numerals, i get too confused trying to figure out which roman numeral = what number!!