Any ACTUAL reason to be cautious about Tylenol in pregnancy?

[biglurker]

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The latest Mount Sinai review criticized that sibling control study in JAMA from 2024, in case anyone wants to bring that up, btw.

What is your NON PARTISAN look of the data on tylenol and pregnancy?

Mount Sinai Study Supports Evidence That Prenatal Acetaminophen Use May Be Linked to Increased Risk of Autism and ADHD | Mount Sinai - New York

www.mountsinai.org

Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - PMC

Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed studies have indicated that pregnant mothers exposed to ...

pmc.ncbi.nlm.nih.gov

New York, NY (August 13, 2025) Researchers at the Icahn School of Medicine at Mount Sinai have found that prenatal exposure to acetaminophen may increase the risk of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD), in children.

The study, published today in BMC Environmental Health, is the first to apply the rigorous Navigation Guide methodology to systematically evaluate the rigor and quality of the scientific literature.
Acetaminophen (often sold under the brand name Tylenol®, and known as paracetamol outside the United States and Canada) is the most commonly used over-the-counter pain and fever medication during pregnancy and is used by more than half of pregnant women worldwide.

Until now, acetaminophen has been considered the safest option for managing headache, fever, and other pain.

Analysis by the Mount Sinai-led team of 46 studies incorporating data from more than 100,000 participants across multiple countries challenges this perception and underscores the need for both caution and further study.

The Navigation Guide Systematic Review methodology is a gold-standard framework for synthesizing and evaluating environmental health data. This approach allows researchers to assess and rate each study’s risk of bias, such as selective reporting of the outcomes or incomplete data, as well as the strength of the evidence and the quality of the studies individually and collectively.

“Our findings show that higher-quality studies are more likely to show a link between prenatal acetaminophen exposure and increased risks of autism and ADHD,” said Diddier Prada, MD, PhD, Assistant Professor of Population Health Science and Policy, and Environmental Medicine and Climate Science, at the Icahn School of Medicine at Mount Sinai. “Given the widespread use of this medication, even a small increase in risk could have major public health implications.”

The paper also explores biological mechanisms that could explain the association between acetaminophen use and these disorders. Acetaminophen is known to cross the placental barrier and may trigger oxidative stress, disrupt hormones, and cause epigenetic changes that interfere with fetal brain development.

While the study does not show that acetaminophen directly causes neurodevelopmental disorders, the research team’s findings strengthen the evidence for a connection and raise concerns about current clinical practices.

The researchers call for cautious, time-limited use of acetaminophen during pregnancy under medical supervision; updated clinical guidelines to better balance the benefits and risks; and further research to confirm these findings and identify safer alternatives for managing pain and fever in expectant mothers.

The study was conducted in collaboration with the University of California, Los Angeles; University of Massachusetts Lowell; and Harvard T.H. Chan School of Public Health.

 

[dchz]

Same as my nonpartisan look on watermelon and kids drowning:

Look at any year. There is a HUGE link between watermelons consumed and kids drowning. Anytime watermelon consumption goes up, kids drown more.

Therefore, I concluded that I should eat watermelons whenever I want because I understand that correlation is not causation and partisan politics don't Trump science.

This is why an educated public is necessary for any democracy. Can't believe we have a thread about this in a forum for Medical Doctors.

 

[TeslaCoil]

The latest Mount Sinai review criticized that sibling control study in JAMA from 2024, in case anyone wants to bring that up, btw.

What is your NON PARTISAN look of the data on tylenol and pregnancy?

Mount Sinai Study Supports Evidence That Prenatal Acetaminophen Use May Be Linked to Increased Risk of Autism and ADHD | Mount Sinai - New York

www.mountsinai.org

Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - PMC

Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed studies have indicated that pregnant mothers exposed to ...

pmc.ncbi.nlm.nih.gov

New York, NY (August 13, 2025) Researchers at the Icahn School of Medicine at Mount Sinai have found that prenatal exposure to acetaminophen may increase the risk of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD), in children.

The study, published today in BMC Environmental Health, is the first to apply the rigorous Navigation Guide methodology to systematically evaluate the rigor and quality of the scientific literature.
Acetaminophen (often sold under the brand name Tylenol®, and known as paracetamol outside the United States and Canada) is the most commonly used over-the-counter pain and fever medication during pregnancy and is used by more than half of pregnant women worldwide.

Until now, acetaminophen has been considered the safest option for managing headache, fever, and other pain.

Analysis by the Mount Sinai-led team of 46 studies incorporating data from more than 100,000 participants across multiple countries challenges this perception and underscores the need for both caution and further study.

The Navigation Guide Systematic Review methodology is a gold-standard framework for synthesizing and evaluating environmental health data. This approach allows researchers to assess and rate each study’s risk of bias, such as selective reporting of the outcomes or incomplete data, as well as the strength of the evidence and the quality of the studies individually and collectively.

“Our findings show that higher-quality studies are more likely to show a link between prenatal acetaminophen exposure and increased risks of autism and ADHD,” said Diddier Prada, MD, PhD, Assistant Professor of Population Health Science and Policy, and Environmental Medicine and Climate Science, at the Icahn School of Medicine at Mount Sinai. “Given the widespread use of this medication, even a small increase in risk could have major public health implications.”

The paper also explores biological mechanisms that could explain the association between acetaminophen use and these disorders. Acetaminophen is known to cross the placental barrier and may trigger oxidative stress, disrupt hormones, and cause epigenetic changes that interfere with fetal brain development.

While the study does not show that acetaminophen directly causes neurodevelopmental disorders, the research team’s findings strengthen the evidence for a connection and raise concerns about current clinical practices.

The researchers call for cautious, time-limited use of acetaminophen during pregnancy under medical supervision; updated clinical guidelines to better balance the benefits and risks; and further research to confirm these findings and identify safer alternatives for managing pain and fever in expectant mothers.

The study was conducted in collaboration with the University of California, Los Angeles; University of Massachusetts Lowell; and Harvard T.H. Chan School of Public Health.

Im a pain physician and my advice to pregnant women is that I prefer they take absolutely nothing because the risks of foreign biochemistry during pregnancy are never a proven zero. And in my opinion any risk is too much risk when it comes to that. Besides, tylenol usually aint gonna cut it so the risk benefit ratio isnt great.

 

[biglurker]

Can't believe we have a thread about this in a forum for Medical Doctors.

So, we’re going to casually throw away science in favor of your essentially layperson viewpoint?

Did you read the article? No.

Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - PMC

Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed studies have indicated that pregnant mothers exposed to ...

pmc.ncbi.nlm.nih.gov

Let me guess, you were one of those wacko ivermectin pushers during covid.

 

[anonperson]

The latest Mount Sinai review criticized that sibling control study in JAMA from 2024, in case anyone wants to bring that up, btw.

What is your NON PARTISAN look of the data on tylenol and pregnancy?

Mount Sinai Study Supports Evidence That Prenatal Acetaminophen Use May Be Linked to Increased Risk of Autism and ADHD | Mount Sinai - New York

www.mountsinai.org

Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - PMC

Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed studies have indicated that pregnant mothers exposed to ...

pmc.ncbi.nlm.nih.gov

New York, NY (August 13, 2025) Researchers at the Icahn School of Medicine at Mount Sinai have found that prenatal exposure to acetaminophen may increase the risk of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD), in children.

The study, published today in BMC Environmental Health, is the first to apply the rigorous Navigation Guide methodology to systematically evaluate the rigor and quality of the scientific literature.
Acetaminophen (often sold under the brand name Tylenol®, and known as paracetamol outside the United States and Canada) is the most commonly used over-the-counter pain and fever medication during pregnancy and is used by more than half of pregnant women worldwide.

Until now, acetaminophen has been considered the safest option for managing headache, fever, and other pain.

Analysis by the Mount Sinai-led team of 46 studies incorporating data from more than 100,000 participants across multiple countries challenges this perception and underscores the need for both caution and further study.

The Navigation Guide Systematic Review methodology is a gold-standard framework for synthesizing and evaluating environmental health data. This approach allows researchers to assess and rate each study’s risk of bias, such as selective reporting of the outcomes or incomplete data, as well as the strength of the evidence and the quality of the studies individually and collectively.

“Our findings show that higher-quality studies are more likely to show a link between prenatal acetaminophen exposure and increased risks of autism and ADHD,” said Diddier Prada, MD, PhD, Assistant Professor of Population Health Science and Policy, and Environmental Medicine and Climate Science, at the Icahn School of Medicine at Mount Sinai. “Given the widespread use of this medication, even a small increase in risk could have major public health implications.”

The paper also explores biological mechanisms that could explain the association between acetaminophen use and these disorders. Acetaminophen is known to cross the placental barrier and may trigger oxidative stress, disrupt hormones, and cause epigenetic changes that interfere with fetal brain development.

While the study does not show that acetaminophen directly causes neurodevelopmental disorders, the research team’s findings strengthen the evidence for a connection and raise concerns about current clinical practices.

The researchers call for cautious, time-limited use of acetaminophen during pregnancy under medical supervision; updated clinical guidelines to better balance the benefits and risks; and further research to confirm these findings and identify safer alternatives for managing pain and fever in expectant mothers.

The study was conducted in collaboration with the University of California, Los Angeles; University of Massachusetts Lowell; and Harvard T.H. Chan School of Public Health.

I still do some obstetrics.

ACOG and the Society of Maternal Fetal Medicine have both come out with statements saying Tylenol is acceptable and there is no link to autism.

They doubled down on it yesterday in response to Trump.

There is some population based evidence for a possible link but not all studies have shown this relationship.

At this point, I tell patients it's still an option but only for a small dose for a limited period of time.

If they can't take anything for pain, I don't care one way or the other to be honest. They'll survive.

 

[kidthor]

Also I'm curious if anyone will change their OR practice based on all of this? During COVID I got all sorts of crazy patient requests which I

I still do some obstetrics.

ACOG and the Society of Maternal Fetal Medicine have both come out with statements saying Tylenol is acceptable and there is no link to autism.

They doubled down on it yesterday in response to Trump.

There is some population based evidence for a possible link but not all studies have shown this relationship.

At this point, I tell patients it's still an option but only for a small dose for a limited period of time.

If they can't take anything for pain, I don't care one way or the other to be honest. They'll survive.

Is fever / untreated fever an issue?

 

[anonperson]

Also I'm curious if anyone will change their OR practice based on all of this? During COVID I got all sorts of crazy patient requests which I

Is fever / untreated fever an issue?

Fever is teratogen especially early in pregnancy.

Pick your poison.

 

[TeslaCoil]

Fever is teratogen especially early in pregnancy.

Pick your poison.

Well that was the one exception they quoted.

 

[dchz]

Where are you? we are positioned similarly, but i seriously doubt the hospital cares. The admins don't give 2 sh1ts about patient safety of your own safety.

I sincerely hope you all get something out of this.



They may also replace you after you die too.
This isn't pessimism it's the truth. At least in my situation:

I am currently a fellow. I volunteered be an ICU attending, no attending pay (I didn't care, just wanted to help).

They had to staff us in an open layout unit (no doors, no negative pressure rooms), with make shift plexiglass and plastic drapes as doors and HEPA filter in the hallways (none in the rooms). When we voiced our concerns before we started, we were told the unit would be a dirty unit since there is no negative pressure room anywhere in the hospital. It would be just as dirty as going into a unit with wooden doors because the rooms would be neutral or positive pressure. We were allowed to be donned in the common area with a Tyvek suit, and an additional layer would be donned when we go into patient's rooms, and the additional layer would be doffed when coming out. The Tyvek suits would allow us to run into a room emergently if there was no other PPE available. the second layer PPE was often not refilled and we would run out regularly. I guess this is as "front-line" as it gets.

It was a sh1t show from the beginning, they gave us the most inexperienced staff possible. CRNAs (who haven't done ICU in 10 years) and Cath lab nurses (who also haven't been in the ICU for longer) staffed as ICU nurses without orientation. From the first night it was a fight with one administrator after another, they initially wanted to staff the nurses 2:1 when the nurses don't even know where anything is (keep in mind the standard is 6 months orientation before any ICU nurse gets to be on their own for 1:1, but all my nurses got thrown in there without a 5 minute orientation). They wanted to send random inappropriate admits of covid negative patients to an open covid positive unit. A typical day for me would be donned in a sweaty Tyvek suit for 12 hours running from room to room doing nursing tasks (to cluster care and minimize people's exposure) on top of all my normal attending duties while fighting random bs demands from administrators. Still, everyone was on board to help and we took care of patients. I wouldn't bat an eye if my own mother was in my own unit. I was proud of the care I provided.

About 10 days in, just when things are finally running smoothly, I get a call from my chairman. Apparently orders from above was given to move all my pts in the ICU to a floor unit with closed wooden doors, with no windows to look into the rooms and doors to be remain closed at all times. Keep in mind we discussed this option from day 1 and it was told to us by infection control that it would be no cleaner or dirtier than our current setup. No official reason was given for the move, although it was rumored that a nurse union rep complained about the working conditions of the ICU. It doesn't matter that it would be a ridiculously dangerous task to move all the critical intubated patients for no reason. It doesn't matter that we voiced the SAME EXACT concerns before we started the ICU. We were ordered to move, with no input from the actual physicians taking care of the patients.

The move occurred the next day. I was the sentinel attending sent up to receive all the patients. Shortly after arrival, an infection control nazi nurse told me to take my Tyvek suit because it's considered dirty. I told her it's a clean suit and we discussed this to be our standard PPE. There was no discussion and I was confronted by several administrators. I reluctantly took off my Tyvek suit and threw it in the trash. Literally a minute later, I was informed that a patient had accidentally extubated.

This was a 46 M with no comorbidities besides obesity, healthier than all the administrators confronting me. He was going to be my first patient that I extube from COVID ARDS under my care. I was pissed. I was not oriented to this unit, I had no clue where anything (PPE, emergent airway equipment, drugs) were located. These people who confronted me took away my protection for this EXACT situation. I had to take the Tyvek suit out of the trashcan and don before I ran into the room. None of those nazis that forced me to doff was in there helping me intubate. I was amazed that this guy lived. This was the 2nd time I had to emergently intubate him. It was purely good luck that there was a nurse in the room in the first place, otherwise he would have been aspirating with his tube feeds for hours. Perhaps he was a cat with 9 lives rather than human.

After I finished in the room, those same Nazis were no where to be seen. So i donned on another PPE that was provided by the unit, prepared for another situation like the one that occurred moments earlier. Moments later, I was told by the senior ICU attending (under the direction of infection control) that I cannot be donned in the common area, because it looks like I was wearing a dirty gown. I ensured her it was a clean gown and I don't want to be unprepared in case another patient extubates, half of the patients from the old unit are still en route to this unit.

"yes you're clean but you look dirty and might scare others"

"why don't we just all donn in the common area like we agreed?"

"because infection control think we would scare other people from other units"

"how is this logically different than a month ago when physicians were not allowed to wear masks because of optics? How are my scrubs any cleaner than a Tyvek suit or a yellow gown?"

"it's not. but you still need to doff. I would understand if you no longer want to be part of this unit"

That was my last day as an ICU attending. The biggest challenge for me that day was not committing physical violence. For the first time on the unit, I wasn't running the list through my head and focused on the differentials of my patients. Instead, I wanted to punch all those people with clipboards that unnecessarily placed all my patients at risk. They are now forcing me to take on additional risk for their optics. My biggest fear during this crisis isn't the patient's disease process, it's the bureaucratic bullsh1t that is allowed to occur during crisis care.

Thanks for being my therapy and letting me vent. The hardest part for me was that i felt like I abandoned all my patients. I feel bad for leaving my colleagues but I personally consider it betrayal that this other ICU attending forced me to doff clean PPE and had the audacity to make decisions on how I protect myself without discussion. I am usually very in control emotionally, but something about these events broke me. At that moment, I realized I wasn't in the right head space to continue working there. I have stopped by the unit several times as part of the intubation team since that day. I know i made the right choice by no longer being in that unit.

On the positive news, that patient I emergently reintubated for the 2nd time is getting better!!!

That pt that I emergently intubated twice eventually died because his trach got dislodged in the CT scanner while they were looking for PEs. There was no PE....

So, we’re going to casually throw away science in favor of your essentially layperson viewpoint?

Did you read the article? No.

Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - PMC

Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed studies have indicated that pregnant mothers exposed to ...

pmc.ncbi.nlm.nih.gov

Let me guess, you were one of those wacko ivermectin pushers during covid.

https://forums.studentdoctor.net/threads/anesthesia-groups-covering-covid-icus.1404363/post-21785177

I was in the thick of it during COVID. Our response and our leader was a stain on our history because the leadership was more concerned about winning than listening to science. It is happening again. I say that as a right-leaning moderate.

 

[anonperson]

Well that was the one exception they quoted.

Patients are usually too dumb to understand the exceptions.

I had a group b strep positive patient refuse antibiotics during labor because she didn't want to expose the baby.

Baby ended up with sepsis and group b strep positive blood cultures.

That worked out well for the patient.

 

[lakersbaby]

Same as my nonpartisan look on watermelon and kids drowning:

Look at any year. There is a HUGE link between watermelons consumed and kids drowning. Anytime watermelon consumption goes up, kids drown more.

Therefore, I concluded that I should eat watermelons whenever I want because I understand that correlation is not causation and partisan politics don't Trump science.

This is why an educated public is necessary for any democracy. Can't believe we have a thread about this in a forum for Medical Doctors.

Sounds like you didn’t read the study and also are attributing what the Dean of harvards public’s health’s own study said to Trump science. They specifically state correlation is not causation however causation can be possible given the strength of the data. Believe what you want but your take doesn’t seem “nonpartisan”.

 

[dchz]

Sounds like you didn’t read the study and also are attributing what the Dean of harvards public’s health’s own study said to Trump science. They specifically state correlation is not causation however causation can be possible given the strength of the data. Believe what you want but your take doesn’t seem “nonpartisan”.

I did read the study.

Meta-analyzing sh1t studies doesn't make your study better. You're just meta-analyzing sh1t.

"We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations."

I don't care if they're the dean of harvards public health. Concluding Tylenol causes anything in pregnancy is such a bullsh1t conclusion that it doesn't even meet high school scientific rigor. Not even one mention of confunders. The Dean of Harvard's Public Health should be fired if this is the scientific method coming out of Harvard.

If you apply to their same methodology to watermelon eating and kids drowning. You would find A STRONGER association. Association DOES NOT MEAN CAUSATION. This paper suggests there MIGHT BE AN ASSOCIATION. The association between watermelon eating and drowning is much stronger.

Concluding that Tylenol MIGHT CAUSE AUTISM from meta analysis that suggest there MIGHT BE ASSOCIATION with NDD (Not Autism spectrum) is asinine.

It blows my mind that I have to type this out on a doctor's forum. 🤯

 

[chessknt]

When asking this question did you stop to see if any non-partisan (ie non-governmental) medical organization with actual experts agreed with these ridiculous conclusions? None of them do. Unless you know more about autism than behavioral pediatricians and more about pregnancy than an obstetrician maybe you should remember that there are non Google experts on these topics and they would have discovered this without the intervention of our current batch of senile ruling septuagenarians.

This whole announcement is a circus designed to distract people, classic flood the zone with random bull****. Doesn't deserve a thread let alone an actual discussion.

 

[anonperson]

One of the major problems is the BS studies keep getting published. These population based studies are cheap to do, don't require any real research infrastructure and keep getting published.

All you need is a statistician and some software.

With AI, you probably won't even need the statistician anymore.

It's such low hanging research.It's research fodder for fellows and early career physicians to pump out papers.

 

[biglurker]

Sounds like you didn’t read the study and also are attributing what the Dean of harvards public’s health’s own study said to Trump science. They specifically state correlation is not causation however causation can be possible given the strength of the data. Believe what you want but your take doesn’t seem “nonpartisan”.

I did read the study.

Meta-analyzing sh1t studies doesn't make your study better. You're just meta-analyzing sh1t.

"We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations."

I don't care if they're the dean of harvards public health. Concluding Tylenol causes anything in pregnancy is such a bullsh1t conclusion that it doesn't even meet high school scientific rigor. Not even one mention of confunders. The Dean of Harvard's Public Health should be fired if this is the scientific method coming out of Harvard.

If you apply to their same methodology to watermelon eating and kids drowning. You would find A STRONGER association. Association DOES NOT MEAN CAUSATION. This paper suggests there MIGHT BE AN ASSOCIATION. The association between watermelon eating and drowning is much stronger.

Concluding that Tylenol MIGHT CAUSE AUTISM from meta analysis that suggest there MIGHT BE ASSOCIATION with NDD (Not Autism spectrum) is asinine.

It blows my mind that I have to type this out on a doctor's forum. 🤯

When asking this question did you stop to see if any non-partisan (ie non-governmental) medical organization with actual experts agreed with these ridiculous conclusions? None of them do. Unless you know more about autism than behavioral pediatricians and more about pregnancy than an obstetrician maybe you should remember that there are non Google experts on these topics and they would have discovered this without the intervention of our current batch of senile ruling septuagenarians.

This whole announcement is a circus designed to distract people, classic flood the zone with random bull****. Doesn't deserve a thread let alone an actual discussion.

Why in 2017, would Tylenol’s maker (Kenvue corporation) say they don’t recommend taking Tylenol during pregnancy then?

Yes, in 2017.

Maybe you are so blinded by your own partisanship…unable to throw away your bias for science…sigh



Even ACOG posted this in 2013:

 

[caligas]

Why in 2017, would Tylenol’s maker (Kenvue corporation) say they don’t recommend taking Tylenol during pregnancy then?

Yes, in 2017.

Maybe you are so blinded by your own partisanship…unable to throw away your bias for science…sigh



Even ACOG posted this in 2013:

We’re starting to think maybe YOUR mom took a bit too much Tylenol while pregnant.

I kid! I kid!

 

[deleted643396]

I tell all my patients now that epidurals and anesthesia cause autism. I mean what’s more likely anyway, a dose of acetaminophen or big whopping neurotoxins circulating around causing autism? I kind of love this timeline right now. I always thought the whole “evidence based medicine” movement was dumb anyway.

 

[dchz]

Make Acetaminophen Great Again!

 

[Direct Laryngoscopy]

https://x.com/tylenol/status/839196906702127106?s=46&t=Y_cD7rJX7wWE7FNUq4MBsQ


If the company says not to take their product during pregnancy, I’m going to take their word for it.

 

[chessknt]

Why in 2017, would Tylenol’s maker (Kenvue corporation) say they don’t recommend taking Tylenol during pregnancy then?

Yes, in 2017.

Maybe you are so blinded by your own partisanship…unable to throw away your bias for science…sigh



Even ACOG posted this in 2013:

Are you linking twitter posts as proof and expecting to be taken seriously? Like you think that the social media manager for ACOG or tylenol trumps actual published policy statements and guidelines by national physician organizations?

Serious question--Are you a physician that still practices? How do you normally consume updates in your field and adjust your practice?

 

[DocVapor]

If the company says not to take their product during pregnancy, I’m going to take their word for it.

All that means is some actuary somewhere decided the potential revenue from selling tylenol to pregnant women was outweighed by the potential cost of lawsuits from women claiming tylenol caused autism.

Come on now since when does anyone trust what a manufacturer says? Did we learn nothing from Perdue Pharma?

 

[anonperson]

Why in 2017, would Tylenol’s maker (Kenvue corporation) say they don’t recommend taking Tylenol during pregnancy then?

Yes, in 2017.

Maybe you are so blinded by your own partisanship…unable to throw away your bias for science…sigh



Even ACOG posted this in 2013:

That ACOG tweet is 12 years old.

This is their most recent statement. An actual advisory statement

Acetaminophen Use in Pregnancy and Neurodevelopmental Outcomes

www.acog.org

 

[DesiredMemberName?]

If the company says not to take their product during pregnancy, I’m going to take their word for it.

"Tylenol is one of the most studied medications in history–and is safe when used as directed by expecting mothers, infants and children," Tylenol's website states. "The facts remain unchanged: over a decade of rigorous research, endorsed by leading medical professionals, confirm there is no credible evidence linking acetaminophen to autism."

Old Tylenol tweet on pregnancy resurfaces after Trump's autism claims

In recent days, Tylenol's 2017 tweet has been flooded by responses and comments.

www.9news.com

 

[Direct Laryngoscopy]

"Tylenol is one of the most studied medications in history–and is safe when used as directed by expecting mothers, infants and children," Tylenol's website states. "The facts remain unchanged: over a decade of rigorous research, endorsed by leading medical professionals, confirm there is no credible evidence linking acetaminophen to autism."

Old Tylenol tweet on pregnancy resurfaces after Trump's autism claims

In recent days, Tylenol's 2017 tweet has been flooded by responses and comments.

www.9news.com

I remember there were reports of increased risk of ADHD Autism and Tourette’s going back 10 years. I could pull up the news reports but it doesn’t make a difference

 

[TeslaCoil]

In my opinion the most credible advice here is to take as little medication of any kind as feasibly possible during pregnancy, and especially during organogenesis. Tylenol included. Any doctor who argues against that logic is a quack, IMHO.

 

[deleted643396]

In my opinion the most credible advice here is to take as little medication of any kind as feasibly possible during pregnancy, and especially during organogenesis. Tylenol included. Any doctor who argues against that logic is a quack, IMHO.

I mean honestly, the safest thing to do is to hermetically seal a pregnant woman in a lead chamber with filtered air to prevent her from any background radiation exposure or environmental infectious or toxin exposure. I suppose we should allow a bit of sunlight for Vit D purposes, but the UV might be risky, so maybe only up to 1hr per day in 20 minute increments. Nutrition is a challenge, but the safest thing is probably a purified shake of some sort that has the appropriately calculated macronutrients and vitamin and minerals necessary to support both mother and fetus at optimal health. Keeping the parturient’s mind active is probably necessary, but I would be suspicious of any form of entertainment that has background electromagnetic radiation. A collection of books and jigsaw puzzles might be the only option. We would have to allow only light-hearted romantic comedy novels because we wouldn’t want to induce a stress response that might cause harm to the fetus.

Any suggestion to liberalize these directives argues against all logic and shows brazen disregard to the sanctity of the developing fetus.

I’m convinced we live in the dumbest society in the history of the planet earth.

 

[dchz]

I mean honestly, the safest thing to do is to hermetically seal a pregnant woman in a lead chamber with filtered air to prevent her from any background radiation exposure or environmental infectious or toxin exposure. I suppose we should allow a bit of sunlight for Vit D purposes, but the UV might be risky, so maybe only up to 1hr per day in 20 minute increments. Nutrition is a challenge, but the safest thing is probably a purified shake of some sort that has the appropriately calculated macronutrients and vitamin and minerals necessary to support both mother and fetus at optimal health. Keeping the parturient’s mind active is probably necessary, but I would be suspicious of any form of entertainment that has background electromagnetic radiation. A collection of books and jigsaw puzzles might be the only option. We would have to allow only light-hearted romantic comedy novels because we wouldn’t want to induce a stress response that might cause harm to the fetus.

Any suggestion to liberalize these directives argues against all logic and shows brazen disregard to the sanctity of the developing fetus.

I’m convinced we live in the dumbest society in the history of the planet earth.

You're crazy. Just practice abstinence. Can't get pregnant if you don't have sex. That's only happened once!

 

[VA Hopeful Dr]

In my opinion the most credible advice here is to take as little medication of any kind as feasibly possible during pregnancy, and especially during organogenesis. Tylenol included. Any doctor who argues against that logic is a quack, IMHO.

Feasibly possible is doing a lot of heavy lifting here.

We're all doctors here, we all do risk/benefit analysis before prescribing or recommending anything. That, to my knowledge, hasn't changed.

 

[Bryan O’Blivion]

Not for the first time, I’ve found myself glad I’m not an OB/GYN.

 

[Gator7]

Most of our l&d patients are on meth and the babies seem to come out okay. So I’m not worried about Tylenol.

 

[TeslaCoil]

Feasibly possible is doing a lot of heavy lifting here.

We're all doctors here, we all do risk/benefit analysis before prescribing or recommending anything. That, to my knowledge, hasn't changed.

So then why does everybody have their panties in a bunch about saying no tylenol? Tylenol is the weakest and mostly useless analgesic. Useful mostly when combined with other agents as a multimodal. This thread is whats re7arded. Im sorry but western society has become so flimsy and weak. People think their every single minor ache MUST be stopped, RIGHT NOW or my doctor isnt doing his job. Its ridiculous. Like tylenol is going to achieve much of anything. If a pregnant patient is in that much need of pain relief you’re probably better off going with a low dose of non-synthetic opiate, PRN use. Avoid the window of organogenesis whenever possible.

Everyones political biases are showing quite obviously on this one. If the left had made the recommendation there would be crickets.

 

[VA Hopeful Dr]

So then why does everybody have their panties in a bunch about saying no tylenol? Tylenol is the weakest and mostly useless analgesic. Useful mostly when combined with other agents as a multimodal. This thread is whats re7arded. Im sorry but western society has become so flimsy and weak. People think their every single minor ache MUST be stopped, RIGHT NOW or my doctor isnt doing his job. Its ridiculous. Like tylenol is going to achieve much of anything. If a pregnant patient is in that much need of pain relief you’re probably better off going with a low dose of non-synthetic opiate, PRN use. Avoid the window of organogenesis whenever possible.

Everyones political biases are showing quite obviously on this one. If the left had made the recommendation there would be crickets.

Nope, I'd still be pissed.

Also, Tylenol is a pretty solid pain medicine. I recommend it all the time with pretty good results. I also think you're getting a skewed view of people in pain. In primary care I see people just work through the pain literally every day.

If memory serves, you're in pain medicine - you get the people who have failed what us in primary care have tried and/or the ones who can't handle a little pain from time to time.

As for the anger, this is going to result in a bunch of lawsuits and pregnant patients demanding narcotics because all the other stuff is no longer safe in pregnancy.

 

[ambiturner]

So then why does everybody have their panties in a bunch about saying no tylenol? Tylenol is the weakest and mostly useless analgesic. Useful mostly when combined with other agents as a multimodal. This thread is whats re7arded. Im sorry but western society has become so flimsy and weak. People think their every single minor ache MUST be stopped, RIGHT NOW or my doctor isnt doing his job. Its ridiculous. Like tylenol is going to achieve much of anything. If a pregnant patient is in that much need of pain relief you’re probably better off going with a low dose of non-synthetic opiate, PRN use. Avoid the window of organogenesis whenever possible.

Everyone’s political biases are showing quite obviously on this one. If the left had made the recommendation there would be crickets.

If you do pain, how would you feel if a member of the federal government, who happened to have previously been a freaking trial lawyer, came out and said epidurals cause dementia/cancer/whatever based on some bad studies? And then that opened you up to lawsuits and freaked out your patients into never wanting procedures again? He just as easily could have picked labor epidurals as there’s been some sketchy studies on that too.

I get trying to minimize meds in pregnancy and studying the causes of autism but the way this was rolled out is the problem.

 

[painquestions8989]

He just as easily could have picked labor epidurals as there’s been some sketchy studies on that too.

Fine by me, labor epidural are elective and I'd be happy to stop doing them if patients don't want them.

 

[Iso4ane]

Per PubMed - Competing interests: Dr. Baccarelli served as an expert witness for the plaintiff’s legal team on matters of general causation involving acetaminophen use during pregnancy and its potential links to neurodevelopmental disorders. This involvement may be perceived as a conflict of interest regarding the information presented in this paper on acetaminophen and neurodevelopmental outcomes. Dr. Baccarelli has made every effort to ensure that this current work—like his past work as an expert witness on this matter—was conducted with the highest standards of scientific integrity and objectivity.

 

[GassYous]

Most of our l&d patients are on meth and the babies seem to come out okay. So I’m not worried about Tylenol.

But they have come out with no teeth right? Meth mouth

 

[agammaglobulin]

One side thinks COVID came from bats. One side thinks Tylenol causes autism. I wonder why the general public has a lack of trust for "experts" and politicians?

 

[Mofeen]

Its funny watching a bunch of communists defend the profit interests of the multi billion dollar pharma industry.

 

[jope]

I wish people could take the politics out of this as it just shows medical science can be just as partisan.

Canadian Media warning about Tylenol a few years ago

 

[K-hole]

It’s not politics, it’s Trump. People can’t take the “Trump” out of it. Why? Because he sounds like an uneducated idiot talking about it on national tv.

 

[Southpaw]

Fine by me, labor epidural are elective and I'd be happy to stop doing them if patients don't want them.

That’s okay to believe personally. At the same time I hope you’d admit they help countless numbers of women through an otherwise difficult labor and should be offered to all women in labor.

 

[MiddleOfNowherrr]

Patients are usually too dumb to understand the exceptions.

I had a group b strep positive patient refuse antibiotics during labor because she didn't want to expose the baby.

Baby ended up with sepsis and group b strep positive blood cultures.

That worked out well for the patient.

Thank you for pointing out what should be so obvious to anyone that treats patients:
Patients are NOT going to understand that there are exceptions and that in those cases the risk/benefit ratio can really change in the favor of taking Tylenol.

 

[Southpaw]

I wish people could take the politics out of this as it just shows medical science can be just as partisan.

Canadian Media warning about Tylenol a few years ago

Then do a real study. Double blinded rct across the world with some real numbers. The study listed in the OP is crap. I haven’t seen anyone try and defend the actually study on its merit.

What should we now offer to women in the first trimester for fever, a known teratogen?

If we want to look at Tylenol more closely, fine. But this was a political gesture by Trump. It isn’t scientific. And it stands to harm a lot of women and their developing fetus. It’s irresponsible. Will women now not treat their fevers? Will they more easily turn to narcotics? He could’ve just as easily said vaccines. Or labor epidurals. Or anything really. You see that right?

Yeah sure, no one should be popping Tylenol willy nilly while pregnant. No one is saying they should.

 

[Radar26]

I’m more interested in why announce this right now? What’s the WH’s motive? These studies are old, nothing really new. Tylenol was never mentioned on the campaign trail- even once RFK jr gets nominated/confirmed the Tylenol issue never really comes up. Most people were much more concerned with RFK jr’s history with anti-vax around that time. What’s going on behind the scenes to motivate them to make this announcement now…

 

[VA Hopeful Dr]

I’m more interested in why announce this right now? What’s the WH’s motive? These studies are old, nothing really new. Tylenol was never mentioned on the campaign trail- even once RFK jr gets nominated/confirmed the Tylenol issue never really comes up. Most people were much more concerned with RFK jr’s history with anti-vax around that time. What’s going on behind the scenes to motivate them to make this announcement now…

He needed something to blame autism on and I think the measles outbreak in Texas made him realize that going after vaccines isn't a smart move politically anymore.

 

[Southpaw]

I’m more interested in why announce this right now? What’s the WH’s motive? These studies are old, nothing really new. Tylenol was never mentioned on the campaign trail- even once RFK jr gets nominated/confirmed the Tylenol issue never really comes up. Most people were much more concerned with RFK jr’s history with anti-vax around that time. What’s going on behind the scenes to motivate them to make this announcement now…

This isn’t the political thread so I’m a little hesitant, but it’s more flooding the zone. No epstein file release. Government first amendment infringement. Government owning stake in private companies. We just bombed some people in the Caribbean and labeled them drug gang after the fact (as if that makes it okay…). Keystone Kash and Bondi bungling everything they touch.

He needed something for the MAHA movement but can’t be honest with the country about what’s actually making Americans unhealthy (lack of exercise and lack of a healthy diet). He latched onto this dumb study out of Harvard Public Health.

It’s become easy to predict the moves that are made. It’s a shame Americans suffer for it.

Before the MAGAs here bite my hand, both sides do this.

 

[TeslaCoil]

Nope, I'd still be pissed.

Also, Tylenol is a pretty solid pain medicine. I recommend it all the time with pretty good results. I also think you're getting a skewed view of people in pain. In primary care I see people just work through the pain literally every day.

If memory serves, you're in pain medicine - you get the people who have failed what us in primary care have tried and/or the ones who can't handle a little pain from time to time.

As for the anger, this is going to result in a bunch of lawsuits and pregnant patients demanding narcotics because all the other stuff is no longer safe in pregnancy.

“Tylenol is a pretty solid pain medicine” 😂
Oohhh k.

Yes double boarded. Anesthesia and pain medicine. It is NOT a “solid” pain medicine. Mild analgesic at best.

 

[TeslaCoil]

If you do pain, how would you feel if a member of the federal government, who happened to have previously been a freaking trial lawyer, came out and said epidurals cause dementia/cancer/whatever based on some bad studies? And then that opened you up to lawsuits and freaked out your patients into never wanting procedures again? He just as easily could have picked labor epidurals as there’s been some sketchy studies on that too.

I get trying to minimize meds in pregnancy and studying the causes of autism but the way this was rolled out is the problem.

Apples to oranges. Epidurals to tylenol? Incomparable.

I agree on poor roll-out though.

 

[TeslaCoil]

I tell all my patients now that epidurals and anesthesia cause autism. I mean what’s more likely anyway, a dose of acetaminophen or big whopping neurotoxins circulating around causing autism? I kind of love this timeline right now. I always thought the whole “evidence based medicine” movement was dumb anyway.

*sloooow clap*

Congratulations on another record broken for ignorance. How often have you had to use epidural and/or general anesthetics during the first half of pregnancy? Probably not many there, genius.

The more you talk, the less I believe you’re a doctor.

 

[deleted643396]

*sloooow clap*

Congratulations on another record broken for ignorance. How often have you had to use epidural and/or general anesthetics during the first half of pregnancy? Probably not many there, genius.

The more you talk, the less I believe you’re a doctor.

Don’t you have fake injections to sell in return for some oxy prescriptions? You are in a fake specialty based on sham procedures. I guess we can still call you doctor if it makes you feel good.