Any suggestions?

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CosmoDaNP

Family Nurse Practitioner
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Sorta hoping someone here can offer up a suggestion or two as on how to proceed with a patient I am currently seeing. I will be seeing him this week and have already spoken with about his situation and honestly I have not one clue on where to proceed.

Firstly, let me say we have absolutely no access locally to a psychiatrist. The nearest psychiatrist is over two hours away. The patient has been seeing a psychologist locally for cognitive behavioral therapy and has made some progress with his anxiety but still has a ways to go.

Current medications are:
Effexor XR 225mg qd
Klonopin .5mg qam
Toprol XL 200 qd (For tachycardia and essential HTN)
(Betablocker could obviously be contributing to his depression however this medication was selected by a highly regarded cardiologist who felt some cardiac issues were being caused by the ACE I and ACE II drugs he had tried and subsequently his symptoms resolved on this medicine).

Patient has a long history of trying other psych medications including Depakote, Lithium, Topamax and Zyprexa for mood stabilization. At one point he was traveling to a psychiatrist and she was working on a dx of Cyclothymia. He has no symptoms of Cyclothymia or any other BP type illness when maintained on Effexor XR. Any other SSRI/SNRI and the symptoms represent.

The issue we're dealing with is a seasonal depression which occurs this time every year. I've been managing this with him and this will be the fifth year it occurs. Usually see it starting in early October and it subsequently resolves in January. Psyc consults in the past have ruled out any SAD, PTSD. The patient cannot provide any explanation as to what may have happened in his life at this time of year to account for any worsening of depression.

Last year I convinced him to return to a psychiatrist in September in hopes of starting some sort of proactive treatment which might avert the "October blues". The psychiatrist started him on Adderall 15mg bid and continued him on that for six months. (And no, I have no idea her logic on that one). This did delay the problem but within a month of stopping the Adderall he complained of worsening depression (which I can't determine if it was simply a delay of his usual problems or was percipitated by the withdrawal of the amphetamine).

So... does anyone or can anyone make any suggestions here? My thinking is to perhaps increase the Effexor XR or start a mood stabilizer? The only thing I can find anywhere on a case like this is using LiCO3 however in that text Lithium was used long term. This patient really just needs a short course of something 1/4 of the year.

Any direction you could provide would be greatly appreciated.
Kinda lost of for a sense of direction at the moment.

Cosmo
 
Ummmm... just as a matter of principle I would have thought getting on the telphone to a decent psychiatrist might be more reliable than posting on a forum like this and getting replies from people of unknown qualification?
 
I've consulted three different psychiatrists who I very much respect however they haven't really been able to offer any suggestions past what I've already considered.

The plan that seems to be the most fitting is to start him on Eskalith CR and titrate to correct levels. If he responded well we could continue it and provide a proactive increase next year for 3-4 months then lower him back to his pre-seasonal doseages.

The other two suggestions were for a Prolixin IM IMJ (nope, moving on) and a short course of Risperdal (which is a drug I have very limited expierence with).

Cosmo
 
I'm just a psych resident, but I might be able to help.

What are the pt's current target sx? How old is the pt? Are there any panic attacks? Past suicide attempts? Why is the pt on an SNRI instead of an SSRI?
 
Currently working with a blanket diagnosis of major depressive disorder and GAD.
Pt is a 27yr white male.

Over the past five years EVERY SSRI has been tried in this patient. All were titrated to maxium dosages and some were augmented with maxium dosage Wellbutrin. Out of despiration I tried Effexor XR and there was an immediate improvement.

He does have a history of panic attacks but these have subsided with CBT and Klonopin .5mg qam. He presents as just a generally anxious person with excessive worry about almost everything.

He does have a hx of a suicide attempt in his early teen years. OD on Ibuprofen which was not discovered for over a week post ingestion. Did have classic symptoms of Ibuprofen OD but was never treated. LFTs are normal to date.

It appears I have failed to mention he is also on Ambien 10mg qhs PRN. I started this because of problems transitioning in to sleep (two-three hours before onset after laying down). The psyc he saw last year referred him for a sleep study (don't have the results in front of me) but it was suggested by their specialist to continue Ambien over the long term. He tells me he takes it every other night or less and I tend to believe that I write #15 per month and have never had any early refill requests.

TIA for any help you can offer up!

Cosmo
 
Presumptive dx BPII(need more info regarding hypomanic=well=non-depressed phase.
lithium, might need some augmentation w/ 2nd/3rd MS. And please do pre-li w/u incl TSH.
my 0.02c 🙂
 
What about ETOH, SA? Is thyroid wnl? MVP? Ambien and klonopin may be an issue that becomes more depressogenic when the days get shorter, but it sounds like there are sound reasons for both. Sleep quality is essential with psych patients and often gets overlooked. More descriptive accounts about target sx, and what is being manifested as depression would help. Does this person have a regular exercise program? If not prescribe one, and get him to stick to it. This is also vital with psych issues and is often overlooked. Meds are great, but often when basic lifestyle issues are overlooked and we rely on meds we get cases like this. Give us more info... 🙂
 
PS. Consider lamotrigine, but start very low and go slow. Tell pt to report any rash immediately to your office...fear is SJS.
 
Negative for ETOH and SA.
Thyroid is WNL.
Negative for MVP per Echo last year.

Assessment for Axis II disorders performed by psychologist. Nothing remarkable there.
Patient does exercize regularly and is fairly active.

I consulted with an attending psch MD at the Univ. Hospital where I trained. Her recomendation (like above) was for Lamactil. Will be starting at 25mg bid x2wks and reassessing for response.

Thanks for all your suggestions. I'll be sure to update you once I see the patient in two weeks.

Cosmo
 
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