You'd certainly be able to manage it in years one and two, although you might come to resent it fairly quickly -- two hours a day is a big chunk of time. If you are able to study while in transit, then that might work. I never managed it, though-- always ended up either distracted or queasy. But if you can do it, that's great.
For the clinical years, remember that sleep will be at a HUGE premium. You don't want to spend any more time than you have to in transit. During an internal medicine rotation, for example, you may have to arrive at 6am and stay until midnight -- or even later on a call night. uffda is correct in that call nights are generally in-house: commuting won't be an option. You'll either be awake on the floor or asleep (briefly) in the call room. Call rooms, by the way, are wee dorm rooms with a bed(s) and a sink -- they may be private, or they may be shared, depending on the hospital. They ain't very homey, but they work just fine. You might find yourself crashing there pretty often on difficult rotations, even when you're not on call. Save yourself the commute.
And one more thing. Please, please make sure that the lines of communication between you and your wife are as open as possible before you start medical school, because it's going to be really tough when you're in the thick of things. I speak from experience: I didn't anticipate any problems when I began my first year, since my husband had seemed 100% supportive of the idea and he's very "low maintenance" anyway. But when I actually began school, and got all stressed out and felt that I had to spend all my time studying and so on, it created a huge strain on our marriage. Threw me for a loop. And yes, we worked it out. And will continue to work it out, even though my upcoming surgery rotation will likely create a whole new set of stresses...
But if your wife ALREADY has her doubts, and you haven't even begun school yet, you two are going to have a LOT of talking to do, or it will get really ugly really quickly.
Sorry, not trying to preach here, just hoping that you can avoid some of these problems before they happen.
Good luck!