Is anyone here using sex hormone replacement therapy for depression. Thyroid axis problems seems more matter of fact, you test the axis on every admission, if you see a problem, you consult and treat. But from my literature searches it seems that there is a growing data base that appear to support sex hormone replacement in certain populations of depressed patients. I'm just curious why I don't hear anything about in my practice circles. Doesn't seem like anybody looks for gonadal axis dysfunction in their depressed patients. Maybe they shouldn't. It just seems like a plausible explanation for many of the subjective and even physical symptoms we look for in depressive disorders.