Step I Arthritis - What type of hypersensitivity?

Started by justadream
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justadream

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On Wikipedia (https://en.wikipedia.org/wiki/Type_IV_hypersensitivity), I see that Rheumatoid Arthritis is classified at Type IV.

In the pathophysiology section of RA on Wiki (https://en.wikipedia.org/wiki/Rheumatoid_arthritis#Pathophysiology), it says"

"RA primarily starts as a state of persistent cellular activation leading to autoimmunity and immune complexes in both joints and other, organs where it manifests."

This suggests it is also Type III hypersensitivity (which is immune complex mediated).

Also, if you just look at the Type III hypersensitivity page, arthritis is mentioned as being Type III (https://en.wikipedia.org/wiki/Type_III_hypersensitivity):

"Hence, vasculitis, glomerulonephritis and arthritis are commonly associated conditions as a result of type III hypersensitivity responses"

So is (rheumatoid) arthiritis both Type III and Type IV?