I think the original purpose of this thread was to discuss clinical data presented at ASTRO. I did not attend but my colleague did and took notes.
Note: Everything is condensed in TL;DR format
1. PACIFIC trial (discussed here on dedicated thread) - Durvalumab added to CRT in Stage III NSCLC benefits ORR, PFS, local PFS, DM PFS, and new brain metastases
2. MDACC Phase I/II trial of Ipi + SBRT in patients with metastatic disease - results highly promising, see press release here:
Radiation-immunotherapy combination can slow tumor growth for some patients with metastatic late-stage cancer - American Society for Radiation Oncology (ASTRO)
3. RTOG 0526 Phase II of LDR salvage after PSA failure after definitive EBRT ADCP - primary endpoint was <= 10% Gr3 GI/GU toxicity; technically not met (14%); but < 20% "unacceptable" rate
4. Stupp GBM EF-14 TTF HRQOL outcomes - Optune added to Stupp regimen increases overall survival by 5 months; no difference in QoL between standard Stupp and Optune
5. Chinese phase III PMRT standard Fx vs. HypoFx non-inferiority trial -50/25 vs 43.5 Gy at 2.9 Gy / fx given daily over 15 fx (3 weeks); equivalent in all ways at five years + SUPERIOR cosmesis for hypofrac arm
6. GOG 249 pelvic EBRT vs. VBT à carbo/taxol in high intermediate risk endometrial CA - EBRT has way better toxicity (probably because of carbo/taxol in other arm) and pelvic control rates slightly favor EBRT
7. IAEA cervix HDR dose/fx trial - 7 Gy x 4 > 9 Gy x 2 in terms of LC
8, UTSW consolidative RT after 1st line systemic therapy for metastatic NSCLC phase IIR - PFS improved from 4 months to 10 months; no in-field failures