which anti tuberculous drugs are safe to use during pregnancy?
att in pregnancy
- Thread starter abi
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Here is a link to an article at www.motherisk.org - a pretty good collection of safety/teratogen articles - http://www.motherisk.org/women/updatesDetail.jsp?content_id=105
Summary of article:
- isoniazid, rifampin and ethambutol are considered safe
- give pyroxidine with isoniazid to prevent depletion...neuro complications
- give oral Vitamin K during last month of pregnancy as rifampin and isoniazid have been associated (by case reports only) with hemmorrhagic disease of the newborn
- Ethambutol is associated with congenital ototoxicity and should not be used in pregnancy
- pyrazidamide isn't routinely given, but can be given if there is demonstrated resistance
- breastfeeding is encouraged if mom is receiving treatment, but is not theraputic or prophylactic for baby
Hope it helps.
Summary of article:
- isoniazid, rifampin and ethambutol are considered safe
- give pyroxidine with isoniazid to prevent depletion...neuro complications
- give oral Vitamin K during last month of pregnancy as rifampin and isoniazid have been associated (by case reports only) with hemmorrhagic disease of the newborn
- Ethambutol is associated with congenital ototoxicity and should not be used in pregnancy
- pyrazidamide isn't routinely given, but can be given if there is demonstrated resistance
- breastfeeding is encouraged if mom is receiving treatment, but is not theraputic or prophylactic for baby
Hope it helps.
