Baclofen MOA?

[metview]

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In FA it says that baclofen "inhibits GABA-B receptors" (pg 499) but everywhere else says that baclofen is a GABA-B agonist? What is going on here?

Thanks

 

[zhopv10]

It is an agonist, but it can act at pre synaptic GABA-B receptors thus inhibiting that neuron. So perhaps what was meant is that it can inhibit the pre synaptic neurons? Anyway, the full mechanism from what I've seen is not fully known so maybe there is some indecision on it. For what it's worth the 2016 FA says "activates GABA-B receptors at spinal cord level, inducing skeletal muscle relaxation"

 

[ninjaman22]

I believe FA fixed that in the errata. That was a mistake.

 

[pzh200707]

FA 2016 corrected it

 

[worldbeater]

To remember Baclofen is used to treat back pain ('b' for back).