Thanks. Awesome advice.This stuff isn't HY but it does show up. And just to add really sad "humor" to this thread, I did over 17,500 unique questions for Step 1.
Know that bacterial resistance is generally plasmid-encoded, except fluoroquinolone resistance, which is chromosome-encoded.
Know that tetracycline resistance is increased efflux / decreased in flux.
Know that aminoglycoside resistance is bacterial adenylation, acetylation or phosphorylation of the drug. I encountered this in two different questions (both were like 20% answered correctly questions).
Know that S. pneumoniae is a natural transformer. If it acquires resistance to a drug, it's because it picked up the gene directly from the outside environment (i.e., no pilus or phage).
The rest you just have to use your intuition. If you know the MOA of chloramphenicol is that it inhibits 50S peptidyltransferase, then the answer might be bacterial "alteration of enzymatic acetylation." They do that to see if you understand what's actually going on.
Hope that helps,
Thanks. Awesome advice.
Any suggestions on which sources to learn this stuff? Cell bio/molec and genetics are def my weaknesses. I have a feeling it would hamper my ability to answer some micro or "experiment" questions.