I've loved my Palm TX, which I've used for almost 3 years, but it has had a lot of problems. My touchscreen developed numerous dead spots within the first 6 months and it has become a pain to write/type anything in. I'm planning on sending it in for repairs (spent extra for an extended warranty), but I haven't yet steeled myself to live without it while it's being fixed. It's also been less stable than Palms have been known for in the past--I've had to do a full reformat & reinstall each program one by one (last time it took about 3 days to do this) about once a year. Otherwise, it would often reboot when I used the "search" functions, reboot when trying to open certain programs, etc.
In general, my dependence on my Palm has been more for ancillary/personal purposes rather than medical. It just isn't practical to turn it on, navigate to the right program, and find what I want in the middle of rounds. I do have a lot of textbooks on it, but it isn't comfortable reading on the little screen--it's easier to read off a computer screen. I originally thought the wireless ability would be crucial, but most of the hospitals I've rotated through don't have wireless on many of the wards. I've since thought that smartphones would resolve this problem as they don't depend on somebody having a wireless network. Patient information managers are useful in theory, but again, I've had so many problems with the touch screen, it's easier to write on a piece of paper.
That being said, I love it for personal purposes. I depend on my calendar, and it also syncs with an online calendar for my family members to check. I also have a little crossword program for those moments (ahem...lectures...) that could use a little attention supplement. There's this eBook program that lets me download electronic books that I borrow from the local library (don't even have to walk in!) that also helps fill in those 5-10 minutes when I am waiting in line for something. And, since the screen is lit up, I can read in bed while the significant other is trying to sleep. Other programs I use all the time - financial tracker, running log, automobile fuel mileage & repair log, mp3 player, movie player....