beta-blockers

[pharma yasmin]

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what is the exact mechanism of action of beta-blockers in treating hypertension ..?

are all beta-blockers have the same antihypertensive efficacy , since they have different pharmacodynamics & pharmacokintics ?

 

[PENVK]

Is this a trick question? Look it up and then tell us about it.

 

[Praziquantel86]

There are good books about this.

 

[BenJammin]

This is first semester pharmacy school stuff. Why would you ask us this question? Either you've had a lapse in judgment by asking us that dumb question or your professors are doing a terrible job.

 

[rxlea]

what is the exact mechanism of action of beta-blockers in treating hypertension ..?

BETA BLOCKER. Where are beta receptors located in the body?

are all beta-blockers have the same antihypertensive efficacy , since they have different pharmacodynamics & pharmacokintics ?

No. Look up selectivity then IV versus PO; then daily dosing (SR) versus BID,.

Hmmm... they don't teach this in your BS in Dubai?

Not even med chem? No mention of chains and selectivity?

No mention of solubility?

What about duration of action?

 

[Lubeckd]

Is this a trick question? Look it up and then tell us about it.

I was going tell her this... Its not hard, go to your pharmacology 1 note, look up Alpha 1-2, and B1-2. See what they do, and what does agonist/antagonist do at these sites. If you dont want to look at your pharmacology notes, you can go on wikipedia.

Also it's patient specific, some patient react better to certain beta blockers. Beta blockers is more used for heart rate. Also some Beta blockers are used in hypertensive emergencies. Question to Yasmin?
Which Beta blocker would be used more in ashtma patients? Beta selective or non selective?

 

[pharma yasmin]

I was going tell her this... Its not hard, go to your pharmacology 1 note, look up Alpha 1-2, and B1-2. See what they do, and what does agonist/antagonist do at these sites. If you dont want to look at your pharmacology notes, you can go on wikipedia.

Also it's patient specific, some patient react better to certain beta blockers. Beta blockers is more used for heart rate. Also some Beta blockers are used in hypertensive emergencies. Question to Yasmin?
Which Beta blocker would be used more in ashtma patients? Beta selective or non selective?

no ofcourse the selective beta blockers are more safer , because selective beta-blokers will bind more avidly to B1-receptor than beta2-receptors ..

and stimulation of Beta2receptors cause relaxation of bronchial smooth muscle so if a nonselctive beta -blocker is taken then it may worsen the case of asthma .


i know all the mechanism o beta blockers ... but i wanted to be sure of its mechanism particularlly in hypertensive patients . and just i wanted to share information with others so if any body have extra info. can share it with me .. this is my point ... and thanks for all your sweet respondes.

 

[pharma yasmin]

BETA BLOCKER. Where are beta receptors located in the body?
No. Look up selectivity then IV versus PO; then daily dosing (SR) versus BID,.

Hmmm... they don't teach this in your BS in Dubai?

Not even med chem? No mention of chains and selectivity?

No mention of solubility?

What about duration of action?

i compare between all the beta-blockers and i notice the difference among them ,but i got confused when i read that statment...

"even though there are important pharmacodynamic and pharmacokinetics differences among the various B-blockers , their is no difference in clinical antihypertensive efficacy" .
present in the Joseph T. DiPiro book of pharmacology

 

[All4MyDaughter]

For the most part, I agree that all oral beta blockers lower blood pressure by about the same amount ("equal anti-hypertensive efficacy") but I'm not saying that you can just pick one and give it to any patient. There is more that goes into the choice of beta blocker than just the potential to lower blood pressure. A lot of it has already been mentioned in this thread. It's also important to note that beta blockers are not first line drugs for hypertension.

 

[rxlea]

i compare between all the beta-blockers and i notice the difference among them ,but i got confused when i read that statment...

"even though there are important pharmacodynamic and pharmacokinetics differences among the various B-blockers , their is no difference in clinical antihypertensive efficacy" .
present in the Joseph T. DiPiro book of pharmacology

Efficacy and effectiveness aren't the same thing. You can't just arbitrarily pick a beta blocker because they lower blood pressure about the same. You have to consider patient factors as others pointed out. I'm sorry I made the assumption that you were going to do that.

But it looks like you answered your own question, kinda.