Aug 4, 2016
3
0
Hi all,

I have a general pharmacology nomenclature question. Is there a difference between a receptor/enzyme inhibitor vs. antagonist vs. blocker? Are these 3 terms interchangeable?

For example:
Proton pump inhibitors (PPIs) are not commonly referred to as proton pump blockers.
Angiotensin receptor blockers (ARBs) are not commonly referred to as angiotensin receptor inhibitors.
Histamine-2 receptor antagonists (H2RAs) are not commonly referred to as histamine-2 receptor inhibitors. I have seen them referred as "histamine-2 blockers".

I already tried searching Google, SDN, and Goodman & Gilman.

Thank you in advance.
 

zelman

7+ Year Member
Nov 27, 2009
3,466
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Status
Pharmacist
Hi all,

I have a general pharmacology nomenclature question. Is there a difference between a receptor/enzyme inhibitor vs. antagonist vs. blocker? Are these 3 terms interchangeable?

For example:
Proton pump inhibitors (PPIs) are not commonly referred to as proton pump blockers.
Angiotensin receptor blockers (ARBs) are not commonly referred to as angiotensin receptor inhibitors.
Histamine-2 receptor antagonists (H2RAs) are not commonly referred to as histamine-2 receptor inhibitors. I have seen them referred as "histamine-2 blockers".

I already tried searching Google, SDN, and Goodman & Gilman.

Thank you in advance.
Typically, blockers are competitive antagonists while inhibitors are allosteric antagonists.
 

npage148

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May 2, 2005
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npage148

Senior Member
10+ Year Member
May 2, 2005
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And SSRIs. Which inhibitors are allosteric?
 
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