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Say if you have a general pathway A --> B --> C --> D
If you have an enzyme deficiency such that the reaction C --> D is not possible, this generally means C will accumulate in relative excess. But shouldn't B and subsequently A accumulate in excess as well (assuming no feedback inhibition)?
If you have an enzyme deficiency such that the reaction C --> D is not possible, this generally means C will accumulate in relative excess. But shouldn't B and subsequently A accumulate in excess as well (assuming no feedback inhibition)?