blood's buffering capacity

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lisichka

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Hemoglobin buffers blood by binding with H+. The higher your hemoglobin levels, the more acid you can deal with, by quickly moving it to your lungs, where it will react with bicarb, form carbonic acid, which will then break down into water and carbon dioxide to be exhaled.

hello,
i encountered a question about blood's buffering capacity in relation to bicarbonate buffering system in one of the kaplan;s exams.
here's the quick recap of the idea:

*Increasing the total volume of blood will increase blood's buffering capacity.
*Increasing only bicarbonate will no do anything to the buffering capacity, but it will increase the basicity of blood.
*The same is with H+, it will not affect the capacity, just will increase the acidity of blood.

I realize that the more volume there is the more difficult it is to change the pH by adding acid or base. But Are there any other factors that effect blood's buffering capacity??????I also think that increasing both absolute concentration of buffer A- (conj acid) and HA (buffer acid) will increase buffering capacity. Is this true?


thank you very much in advance
 
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