Bohr effect and Haldane effect

[nknhatkhanh]

Can some one justify this concept for me please ?

Bohr effect
1. High CO2 in hemoglobin --> high H+ --> Low pH (acidic) --> decrease O2 binding affinity to hemoglobin
2. Low CO2 in hemoglobin --> low H+ --> high pH (basic) --> increase O2 binding affinity to hemoglobin

Haldane effect (opposite with Bohr effect)
1. High in O2 in hemoglobin --> decrease in Co2 binding affinity to hemoglobin
2. Low in O2 in hemoglobin --> increase in Co2 binding affinity to hemoglobin

A lot of thanks first

 

[zEkii]

Yes. Also just for extra knowledge purpose, another note to put in...
Myoglobin has a higher affinity for O2 then hemoglobin.
Myglobin is also a monomer and not a tetramer like a hemoglobin.

 

[orgoman22]

Can some one justify this concept for me please ?

Bohr effect
1. High CO2 in hemoglobin --> high H+ --> Low pH (acidic) --> decrease O2 binding affinity to hemoglobin
2. Low CO2 in hemoglobin --> low H+ --> high pH (basic) --> increase O2 binding affinity to hemoglobin

Haldane effect (opposite with Bohr effect)
1. High in O2 in hemoglobin --> decrease in Co2 binding affinity to hemoglobin
2. Low in O2 in hemoglobin --> increase in Co2 binding affinity to hemoglobin

A lot of thanks first

Yes, you are correct. You understand the concept.

But, remember, there are combination of factors that can control the affinity of Hemoglobin to Oxygen. High CO2 concentration will cause an increase in Carbonic acid concentration, because Carbonic anhydrase will convert CO2 to H2CO3. Carbonic acid will dissociate in blood and release H+ ions, therefore reducing the affinity of Oxygen to Hemoglobin.

The latter concept is the cause of respiratory acidosis.

Hope this helps.