Pros and Cons of seperate etch/bond vs. "one step" etch and bond.
Pros of "one step" - less materials, less steps, less chances for operator error (assuming you follow the directions).
Cons of "one step" - lower bond stregths, in reality doesn't save as much time as the manufacturer claims leed one to believe, can't use with dual cure cements/core build up materials
Pros of seperate etch/bond - long standing tried and true chemistry, relatively easy to use, greater bond strengths than "one step", can use with dual cure cements/core build up materials
Cons of seperate etch/bond - extra steps, *may* have greater post-op sensitivity.
From my own clinical experience, I've been a user of the 5th generation (seperate etch/bond) almost my entire career, and I do keep trying other bonding agents and keep going back to my "old faithfull" bonding agent (I use Jeneric Pentron's Bond-1). I like it because it's easy for me to use in my hands, and I have very low post treatment sensitvity issues with it. I started using some of the self etching "one step" systems (6th generation opti-bond solo+ and a 7th generation I-Bond). I found very similiar low sensitivity issues, but I would see some marginal discoloration multiple months out. I did not see anything resembling the decreased bond strengths reports on clinical observations.
In general, what many manufactuers are promoting as a benefit of the self etching bonding agents is lower sensitivty due to the smear plugs remaining intact and occulding the tubules. Often with seperate etch/bond systems the post op sensitivty will be due to inadequate "volumes" of bonding agent being applied. i.e. if the manufacturer says "apply liberally", then put ALOT of coats on there with a SATURATED brush or else your much more likely to hear your patients complaining of post bonding sensitivity.