I am a bit confused. I understand this toxin block Ach at the presynaptic membrane of PNS and autonomic nerve junctions. Does it do anything to the sympathetics?
botox works via inhibiting the release of Ach. Thus, you use it for muscle relaxation (wrinkle removal). And the locations that Ach is used as a neurotransmiter is as follows:
Parasymp: both at pre-ganglionic and post-ganglionic sites
Symp: only at pre-ganglionic sites. And the only post-ganglionic structure using Ach is the sweat glands.
Ach is involved in Adrenal Medulla, leading to Epi, NE release.
Finally, Ach is involved in innerating the skeletal muscles.
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