Step I Botulism toxin

[monet]

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I am a bit confused. I understand this toxin block Ach at the presynaptic membrane of PNS and autonomic nerve junctions. Does it do anything to the sympathetics?

 

[optiplex]

hey monet:

this is just my understanding:

botox works via inhibiting the release of Ach. Thus, you use it for muscle relaxation (wrinkle removal). And the locations that Ach is used as a neurotransmiter is as follows:

Parasymp: both at pre-ganglionic and post-ganglionic sites
Symp: only at pre-ganglionic sites. And the only post-ganglionic structure using Ach is the sweat glands. 😀

Ach is involved in Adrenal Medulla, leading to Epi, NE release.
Finally, Ach is involved in innerating the skeletal muscles.

I hope this helps...

optiplex