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Botulism toxin

Discussion in 'Step I' started by monet, May 4, 2004.

  1. monet

    monet Senior Member
    7+ Year Member

    Sep 24, 2002
    Likes Received:
    I am a bit confused. I understand this toxin block Ach at the presynaptic membrane of PNS and autonomic nerve junctions. Does it do anything to the sympathetics?
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  3. optiplex

    optiplex Member
    7+ Year Member

    Feb 27, 2004
    Likes Received:
    hey monet:

    this is just my understanding:

    botox works via inhibiting the release of Ach. Thus, you use it for muscle relaxation (wrinkle removal). And the locations that Ach is used as a neurotransmiter is as follows:

    Parasymp: both at pre-ganglionic and post-ganglionic sites
    Symp: only at pre-ganglionic sites. And the only post-ganglionic structure using Ach is the sweat glands. :D

    Ach is involved in Adrenal Medulla, leading to Epi, NE release.
    Finally, Ach is involved in innerating the skeletal muscles.

    I hope this helps...


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