Pertussis toxin MOA

[cbrons]

Pertussis toxin is an ADP ribosylating A-B toxin with two components:

1. A (Active) component ADP-ribosylates Gi by removing the ADP-ribosyl group from NAD and covalently attaching it to Gi which causes Gi inactivation and subsequently increased cAMP, increased secretion of Na+, Cl-, H2O from cells, edema, and neutrophil dysfunction.
2. B (Binding) component facilitates endocytosis.

^ is this more or less accurate?

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[seminoma]

Yes. Firecracker is correct