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Pertussis toxin is an ADP ribosylating A-B toxin with two components:
^ is this more or less accurate?
- A (Active) component ADP-ribosylates Gi by removing the ADP-ribosyl group from NAD and covalently attaching it to Gi which causes Gi inactivation and subsequently increased cAMP, increased secretion of Na+, Cl-, H2O from cells, edema, and neutrophil dysfunction.
- B (Binding) component facilitates endocytosis.
^ is this more or less accurate?
