I have always wondered what the "real" difference is between brand and generic (beyond the obvious stuff). I've been thinking about it more lately because over the weekend my father in law mentioned that he "can't" take generics - they make him sick to his stomach (he says). Then, earlier today on a completely unrelated forum, I see this post: "I hesitated posting this but a dear friend is expecting her 3rd due to a generic OC. FWIW, an FYI - Generics can be good but many are unaware of their huge window of efficacy error. Generics are NOT always the same. In some RX categories, the patient / consumer needs to be VERY VERY careful. By Federal Law (FDA) generics need ONLY fall between 80% - 125% of the active ingredients bioequivalency. Unlike BRANDed drugs that are REQUIRED to reach 100% in each and every tablet. Generics are not regulated the same way and there is a huge margin of potential error. That means in terms of birth control, when using a generic you may be getting 100% of what is preventing pregancy -- OR you may be getting ONLY 80% of the active ingredients preventing pregnancy. Thats quite a risk! Will 80% of the active ingredient(s) be enough to prevent pregnancy? Having 20% less of some drugs may not make much difference (??!!) but when a life may be created, you would want the assurance of 100% covereage. I don't know.... what price do you place on preventing pregancy? http://en.wikipedia.org/wiki/Bioequivalence (read towards the bottom under bioequivalence) HTH." I call BS on this and I looked it up on the FDA website (basically says that brand and generic have equivalent action and contain the same active ingredient). I believe bioequivalency studies are done prior to marketing a generic and the 80-125% acceptance criteria are for that specific study - NOT that there may only be 80% active ingredient in your generic med. I thought the accepted active ingredient ranges were 90-110% or 85-115% depending on the potencey/dose of medication (and I'm sure that 100% is not required anywhere, of anyone). And if a drug isn't efficacious at 85-115% range, it won't be approved (right?). Anyway, just wondering what people think of the post (in red) and what do you tell people or discuss with them regarding brand name vs. generic drugs. TIA!