Bromocriptine mesylate is a dopamine receptor agonist, which activates post-synaptic dopamine receptors. The dopaminergic neurons in the tuberoinfundibular process modulate the secretion of prolactin from the anterior pituitary by secreting a prolactin inhibitory factor (thought to be dopamine); in the corpus striatum the dopaminergic neurons are involved in the control of motor function. Clinically, bromocriptine mesylate significantly reduces plasma levels of prolactin in patients with physiologically elevated prolactin as well as in patients with hyperprolactinemia. The inhibition of physiological lactation as well as galactorrhea in pathological hyperprolactinemic states is obtained at dose levels that do not affect secretion of other tropic hormones from the anterior pituitary. Experiments have demonstrated that bromocriptine induces long lasting stereotyped behavior in rodents and turning behavior in rats having unilateral lesions in the substantia nigra. These actions, characteristic of those produced by dopamine, are inhibited by dopamine antagonists and suggest a direct action of bromocriptine on striatal dopamine receptors.HiddenTruth said:What is the pathology and pharmacology associated with such treatment? thanks
rxlist. I found it when I was trying to determine the answer for myself. I don't know if it was of any use to you, though.HiddenTruth said:So where did you copy and paste this from
Pathophysiology for the Wards and Boards by Carlos Ayala.ericdamiansean said:where is this RX list?
btw, anyone know of a really good pathophysio book? seems like every doc I know nowadays when I'm in the hospital wants to know about the pathophysio of every single darn thing..and they get tested in the exams as well..and not that lange book..doesn't work too well