nebulized long-acting beta-agonist.
I've only prescribed Brovana once. It was for a patient I saw, self-referred from her PCP. The patient couldn't tolerate foradil or serevent (and has symptomatic COPD). Her reactions were bad enough that she never wanted to try them again (Advair/Symbicort was a non-starter now since she didn't tolerate the above, and was not interested). But she wanted something to help her. She was already on other medications for her COPD.
In addition to non-pharmaceutical treatments that I suggested, I mentioned Brovana. I told her that her insurance will likely not cover it and she will likely have to pay out of pocket. She wanted to try it.
I wrote for it. Pharmacist called me an hour later saying insurance require prior auth. I filled out the paperwork (expecting it to be denied, but that's what I told the patient) - it was denied (with a phone number for appeal). Called the phone number (I had a cancellation so had time) ... and 1 hr later, surprisingly, had it authorized.
She actually got relief with it. And her side effects were minimal. But that's n=1 (and I loathe to write for it again given the trouble I had to go through to get it approved)