Butrans- cardiac arrhythmia risk?

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High doses, QTc prolonged.

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Ventricular arrhythmia or cardiac arrest was reported in 1.8% of buprenorphine cases compared with 11.6% of methadone cases. Similarly, 0.3% of buprenorphine cases reported QTc prolongation/torsade de pointes compared with 2.6% of methadone cases. Torsade de pointes was reported in 0.1% of buprenorphine cases compared with 1.7% of methadone cases.
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Generally not the sole agent involved.
Generally seems to require twice the maximum dosage of Butrans patches, so likely not a problem for pain physicians unless using very high dose Belbuca or Suboxone.
 
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