This is an interesting one. In my case, I got a C+ in Calc I, but aced Calc II, including receiving an award for some stuff related to it. The initial grade was not at all due to myself, it was an ethical issue with the professor, along with issues regarding her exams and teaching and politics within the institution and her not upholding her duties as a professor (we're talking her missing more than 1/3 of the classes, along with mismatched exams, and lack of even grading them). I refused to take the course over, and went to Calc II and scored an A. I had opportunities to speak directly with those responsible for admitting students into various medical programs, and I asked about this and they said that even they can see no one goes from a C+ to an A with awards in a major course like that without mastering fundamentals in the first part. They said it did raise flags only in them wanting to know what happened and how I pulled it off. Luckily, she liked me, as she failed everyone except for a few. The best was the 25 page take-home tests she would give us, saying it's only 2-3 hours of work. Several of us worked on them for 9-10 hours, only making it to page 6-7 due to the need for actually researching rules that were not in the scope of the course. She also never handed back exams, so none of us knew how good or bad we did.
I can't state how it will work in Orgo, since it's a major course that's used as a restriction, but I would look into taking Orgo I again, then taking II because unless you've mastered part I, you're not going to master II, and that's going to be two mediocre grades there.